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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

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Abstract

We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.

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Authors and Affiliations

  1. Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, SK1O 4TJ, UK

    Isabelle Issemann & Stephen Green

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  1. Isabelle Issemann
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  2. Stephen Green
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Issemann, I., Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645–650 (1990). https://doi.org/10.1038/347645a0

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