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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

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Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

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References

  1. McLaren, A. Trends Genet. 4, 153–157 (1988).

    Article  CAS  PubMed  Google Scholar 

  2. Ferguson, M. W. J. & Joanen, T. Nature 296, 850–853 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Hodgkin, J. Nature 344, 721–728 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Ford, C. E., Jones, K. W., Polani, P. E., de Almeida, J. C. & Briggs, J. H. Lancet i, 711–713 (1959).

    Article  Google Scholar 

  5. Jacobs, P. A. & Strong, J. A. Nature 183, 302–303 (1959).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Welshons, W. J. & Russell, L. B. Proc. natn. Acad. Sci. U.S.A. 45, 560–566 (1959).

    Article  ADS  CAS  Google Scholar 

  7. Burgoyne, P. S. Phil. Trans. R. Soc. Lond. 322, 63–72 (1988).

    Article  CAS  Google Scholar 

  8. McLaren, A. Phil. Trans. R. Soc. Lond. 322, 3–9 (1988).

    Article  CAS  Google Scholar 

  9. Borum, K. Expl Cell Res. 24, 495–507 (1961).

    Article  CAS  Google Scholar 

  10. Burgoyne, P. S. Nature 342, 860–862 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Merchant, H. Devl Biol. 44, 1–21 (1975).

    Article  CAS  Google Scholar 

  12. McLaren, A., in The Origin and Evolution of Sex (eds Halvorsen, H. O. & Monroy, A.) 289–300 (Liss, New York, 1985).

    Google Scholar 

  13. Ferguson-Smith, M. A., Affara, N. A. & Magenis, R. E. Development 101(Suppl.), 41–50 (1987).

    PubMed  Google Scholar 

  14. Affara, N. A. et al. Nucleic Acids Res. 15, 7325–7342 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Bishop, C. E., Boursot, P., Baron, B., Bonhomme, F. & Hatat, D. Nature 315, 70–72 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Weissenbach, J., Levilliers, J., Petit, C., Rouyer, F. & Simmler, M.-C. Development 101, 67–74 (1987).

    PubMed  Google Scholar 

  17. Palmer, M. S. et al. Nature 342, 937–939 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Page, D. C. et al. Cell 51, 1091–1104 (1987).

    Article  CAS  PubMed  Google Scholar 

  19. Sinclair, A. H. et al. Nature 346, 240–244 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Jantzen, H.-M. et al. Nature 344, 830–836 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Kelly, M., Burke, J., Smith, M., Klar, A. & Beach, D. EMBO J. 7, 1537–1547 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Cattanach, B. M., Pollard, C. E. & Hawkes, S. G. Cytogenetics 10, 318–337 (1971).

    Article  CAS  PubMed  Google Scholar 

  23. Evans, E. P., Burtenshaw, M. D. & Cattanach, B. M. Nature 300, 443–445 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. McLaren, A. et al. Proc. natn. Acad. Sci. U.S.A. 85, 6442–6445 (1988).

    Article  ADS  CAS  Google Scholar 

  25. Roberts, C. et al. Proc. natn. Acad. Sci. U.S.A. 85, 6646–6649 (1988).

    Google Scholar 

  26. Sutcliffe, M. J. & Burgoyne, P. S. Development 107, 373–380 (1989).

    CAS  PubMed  Google Scholar 

  27. Simpson, E., Edwards, P., Wachtel, S., Mclaren, A. & Chandler, P. Immunogenetics 13, 355–358 (1981).

    Article  CAS  PubMed  Google Scholar 

  28. McLaren, A., Simpson, E., Tomonari, K., Chandler, P. & Hogg, H. Nature 312, 552–555 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  29. Burgoyne, P. S., Levy, E. R. & McLaren, A. Nature 320, 170–172 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Nagamine, C. M., Chan, K., Kozak, C. A. & Lau, Y.-F. Science 243, 80–83 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Mardon, G. et al. Science 243, 78–80 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  32. Koopman, P. et al. Nature 342, 940–942 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Nagamine, C. M., Chan, K., Hake, L. E. & Lau, Y.-F. Genes Dev. 4, 63–74 (1990).

    Article  CAS  PubMed  Google Scholar 

  34. Singh, L., Phillips, C. & Jones, K. W. Cell 36, 111–120 (1984).

    Article  CAS  PubMed  Google Scholar 

  35. Lovell-Badge, R. H. & Robertson, E. Development 109, 635–646 (1990).

    CAS  PubMed  Google Scholar 

  36. Gubbay, J., Koopman, P., Collignon, J., Burgoyne, P. & Lovell-Badge, R. Development 109, 647–653 (1990).

    CAS  PubMed  Google Scholar 

  37. Kozak, M. Nucleic Acids Res. 15, 8125–8148 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Cunliffe, V., Koopman, P., Mclaren, A. & Trowsdale, J. EMBO J. 9, 197–205 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Fahrner, K., Hogan, B. L. M. & Flavell, R. EMBO J. 6, 1265–1271 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Einck, L. & Bustin, M. Expl Cell Res. 156, 295–310 (1985).

    Article  CAS  Google Scholar 

  41. Wolgemuth, D. J. et al. Proc. natn. Acad. Sci. U.S.A. 84, 5813–5817 (1987).

    Article  ADS  CAS  Google Scholar 

  42. Gaunt, S. J., Krumlauf, R. & Duboule, D. Development 107, 131–141 (1989).

    CAS  PubMed  Google Scholar 

  43. Burgoyne, P. S., Buehr, M., Koopman, P., Rossant, J. & Mclaren, A. Development 102, 443–450 (1988).

    CAS  PubMed  Google Scholar 

  44. Molecular Cloning: A Laboratory Manual 2nd edn (eds Sambrook, J., Fritsch, E. F. & Maniatis, T.) (Cold Spring Harbor Laboratory, New York, 1989).

  45. Devereux, J., Haeberli, P. & Smithies, O. Nucleic Acids Res. 12, 387–395 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. Peter Goodfellow: Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK

Authors and Affiliations

  1. Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    John Gubbay, Jérôme Collignon, Peter Koopman, Blanche Capel, Androulla Economou, Andrea Münsterberg, Nigel Vivian, Peter Goodfellow & Robin Lovell-Badge

Authors
  1. John Gubbay
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  2. Jérôme Collignon
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  3. Peter Koopman
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  4. Blanche Capel
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  5. Androulla Economou
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  6. Andrea Münsterberg
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  7. Nigel Vivian
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  8. Peter Goodfellow
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  9. Robin Lovell-Badge
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Gubbay, J., Collignon, J., Koopman, P. et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346, 245–250 (1990). https://doi.org/10.1038/346245a0

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