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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

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Abstract

The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes,oct-3 is expressed in the totipotent and pluripotent stem cells of the pre-gastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

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Author information

Author notes

  1. Francoise Poirie

    Present address: Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York, 10032, USA

Authors and Affiliations

  1. Metabolism Branch, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Mitchell H. Rosner, M. Alessandra Vigano & Louis M. Staudt

  2. Howard Hughes Medical Institute, Bethesda, Maryland, 20892, USA

    Mitchell H. Rosner

  3. Department of Pathology, Georgetown University Medical School, Washington, DC, 20057, USA

    Mitchell H. Rosner

  4. Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, Maryland, 20892, USA

    Keiko Ozato

  5. Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Paula M. Timmons, Francoise Poirie & Peter W. J. Rigby

Authors
  1. Mitchell H. Rosner
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  2. M. Alessandra Vigano
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  3. Keiko Ozato
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  4. Paula M. Timmons
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  5. Francoise Poirie
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  6. Peter W. J. Rigby
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  7. Louis M. Staudt
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Rosner, M., Vigano, M., Ozato, K. et al. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345, 686–692 (1990). https://doi.org/10.1038/345686a0

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  • DOI: https://doi.org/10.1038/345686a0

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