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Association of CD2 and CD45 on human T lymphocytes

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Abstract

AT least two membrane receptors have been defined through which human T lymphocytes can be induced to proliferate and differentiate, namely the CD3-Ti antigen receptor complex1 and the CD2 molecule2. Monoclonal antibodies directed at either CD2 or CD3 induce intracellular second messenger production and subsequent protein phosphorylation3–5. On most human non-B lymphocytes, CD3-Ti and CD2 are coexpressed and seem to be functionally interrelated6. But there are minor subpopulations in which these receptor systems can transduce signals despite a mutually exclusive expression7,8, indicating that CD3-Ti and CD2 can act independently of each other. This view is supported by the finding that most monoclonal antibodies directed at the CD45 molecules9,10 are strongly co-mitogenic with CD2 but not CD3 monoclonal antibodies (refs 11,12). As the intracytoplasmic domains of CD45 have tyrosine phosphatase activity13 these functional effects11,12 could be explained by a physical association between CD2 and CD45. Using chemical crosslinking techniques, we now show that CD45 is linked to CD2 on the surface of human T lymphocytes.

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Author notes

  1. Peter Altevogt: Abteilung Zelluläre Immunologie, Institut für Immunologie und Genetik, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900 Heidelberg FRG

Authors and Affiliations

  1. Abteilung Angewandte Immunologie, Institut für Radiologie und Pathophysiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900, Heidelberg, FRG

    Burkhart Schraven, Yvonne Samstag, Peter Altevogt & Stefan C. Meuer

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  1. Burkhart Schraven
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  2. Yvonne Samstag
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  3. Peter Altevogt
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  4. Stefan C. Meuer
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Schraven, B., Samstag, Y., Altevogt, P. et al. Association of CD2 and CD45 on human T lymphocytes. Nature 345, 71–74 (1990). https://doi.org/10.1038/345071a0

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