Skip to main content

Advertisement

SpringerLink
Log in

Virus-induced autoantibody response to a transgenic viral antigen

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE induction of autoantibodies and their possible role in the pathogenesis of autoimmune disease are poorly understood. Involvement of infectious agents has been suspected, but direct evidence is sparse1–4. Whether immunological unresponsiveness to self by antibody-forming ? cells is maintained by clonal abortion5, clonal anergy6–8 or suppression9, or how the scenario of interactions between helper T cells, B cells and antigen-presenting cells10,11–13 is distorted in autoantibody responses, is being analysed and widely debated3,6–8,14–17. To evaluate tolerance of neutralizing B-cell responses12,18 we used transgenic mice expressing the cell membrane associated glycoprotein (G) of vesicular stomatitis virus (VSV) as self-antigen. We show that autoantibodies to VSV-G cannot be induced by VSV-G in adjuvant or by recombinant vaccinia virus expressing VSV-G, but are triggered by infection with wild-type VSV. The data show that helper T-cell tolerance is crucial in maintenance of B-cell non-reactivity2,16,19,20 and that cognate T–B recognition is necessary to break tolerance of self-reactive B cells. These results may help to understand mechanisms of virus-induced autoimmunity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Talal, N. in Autoimmunity (ed. Talal, N.) 1–734 (Academic, San Francisco, 1977).

    Google Scholar 

  2. Weigle, W. O. Adv. Immun. 16, 61–122 (1973).

    Article  CAS  Google Scholar 

  3. Oldstone, M. B. A., Schwimmbeck, P., Dyrberg, T. & Fujinami, R. Prog. Immun. 6, 787–795 (1986).

    Article  Google Scholar 

  4. Mims, C. A. Pathogenesis of Infectious Disease (Academic, London, 1982).

    Google Scholar 

  5. Nemazee, D. A. & Bürki, K. Nature 337, 562–566 (1989).

    Article  ADS  CAS  Google Scholar 

  6. Nossal, G. J. V. Science 245, 147–153 (1989).

    Article  ADS  CAS  Google Scholar 

  7. Goodnow, C. C. et al. Nature 334, 676–682 (1988).

    Article  ADS  CAS  Google Scholar 

  8. DeFranco, A. L. Nature 342, 340–341 (1989).

    Article  ADS  CAS  Google Scholar 

  9. Gershon, R. K. & Kondo, K. Immunology 18, 723–737 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Lanzavecchia, A. Curr. Top. Microbiol. Immun. 130, 65–78 (1986).

    CAS  Google Scholar 

  11. Mitchison, N. A. Eur. J. Immun. 1, 10–17 (1971).

    Article  CAS  Google Scholar 

  12. Zinkernagel, R. M., Rüedi, E., Althage, A., Hengartner, H. Reimann, G. J. exp. Med. 168, 1187–1192 (1988).

    Article  CAS  Google Scholar 

  13. Vercelli, D., Jabara, H. H., Arai, K. & Geha, R. S. J. exp. Med. 169, 1295–1307 (1989).

    Article  CAS  Google Scholar 

  14. Bretscher, P. Cell. Immun. 6, 1–11 (1973).

    Article  CAS  Google Scholar 

  15. Langman, R. E. The Immune System (Harcourt Brace Jovanovich, San Diego, 1989).

    Google Scholar 

  16. Mitchison, N. A. Proc. R. Soc. B161, 275–292 (1964).

    ADS  CAS  Google Scholar 

  17. Schwartz, R. H. Cell 57, 1073–1081 (1989).

    Article  CAS  Google Scholar 

  18. Gupta, S. C., Hengartner, H. & Zinkernagel, R. M. Proc. natn. Acad. Sci. U.S.A. 83, 2604–2608 (1986).

    Article  ADS  CAS  Google Scholar 

  19. Harris, D. E., Cairns, L., Rosen, F. S. & Borel, Y. J. exp. Med. 156, 567–584 (1982).

    Article  CAS  Google Scholar 

  20. Lake, P. & Mitchison, N. A. Cold Spring Harbor Symp. quant. Biol. 41, 589–595 (1977).

    Article  Google Scholar 

  21. Zinkernagel, R. M. & Rosenthal, K. L. Immunol. Rev. 58, 131–155 (1981).

    Article  CAS  Google Scholar 

  22. Yewdell, J. W. et al. J. exp. Med. 163, 1529–1538 (1986).

    Article  CAS  Google Scholar 

  23. Kelley, J. M., Emerson, S. U. & Wagner, R. R. J. Virol. 10, 1231–1235 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Lefrançois, L. & Lyles, D. S. Virology 121, 157–167 (1982).

    Article  Google Scholar 

  25. Mills, B. J., Beebe, D. P. & Cooper, N. R. J. Immun. 123, 2518–2524 (1979).

    CAS  PubMed  Google Scholar 

  26. Goodnow, C. C. Crosbie, J., Jörgensen, H., Brink, R. A. & Basten, A. Nature 342, 385–391 (1989).

    Article  ADS  CAS  Google Scholar 

  27. Gallione, C. & Rose, J. K. J. Virol. 46, 162–169 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. VandePol, S. B., Lefrançois, L. & Holland, J. J. Virology 148, 312–325 (1986).

    Article  CAS  Google Scholar 

  29. Karupiah, G. et al. J. Immun. 144, 290–298 (1990).

    CAS  PubMed  Google Scholar 

  30. Falke, D. & Rowe, W. P. Arch. ges. Virusforsch. 17, 549–559 (1965).

    Article  CAS  Google Scholar 

  31. Theofilopoulos, A. T. & Dixon, F. J. Adv. Immun. 28, 89–221 (1979).

    Article  CAS  Google Scholar 

  32. Möller, G. Immunol. Rev. 23, 126–137 (1975).

    Article  Google Scholar 

  33. Milich, D. R. Immun. Today 9, 380–386 (1988).

    Article  CAS  Google Scholar 

  34. Scherle, P. A. & Gerhard, W. J. exp. Med. 164, 1114–1128 (1986).

    Article  CAS  Google Scholar 

  35. Brett, S. J., Cease, K. B. & Berzofsky, J. A. J. exp. Med. 168, 357–373 (1988).

    Article  CAS  Google Scholar 

  36. Bodmer, H. C., Gotch, F. M. & McMichael, A. J. Nature 337, 653–655 (1989).

    Article  ADS  CAS  Google Scholar 

  37. Finnegan, A. & Amburgey, C. F. J. exp. Med. 170, 2171–2176 (1989).

    Article  CAS  Google Scholar 

  38. Carbone, F. R., Moore, M. W., Sheil, J. M. & Bevan, M. J. J. exp. Med. 167, 1767–1779 (1988).

    Article  CAS  Google Scholar 

  39. Rose, J. K. & Gallione, C. J. J. Virol. 39, 519–528 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Kenney, Sh., Natarajan, V., Strike, D., Khoury, G. & Salzman, N. P. Science 226, 1337–1339 (1984).

    Article  ADS  CAS  Google Scholar 

  41. Benoist, C. & Chambon, P. Nature 290, 304–310 (1981).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Jasemine Chambers

    Present address: Patent and Trade Mark Office, Group 180, Crystal Plaza 2, Arlington, Virginia, 22202, USA

Authors and Affiliations

  1. Laboratory of Experimental Pathology, Institute of Pathology,University of Zurich, Switzerland

    Rolf M. Zinkernagel, Suzanne Cooper & Hans Hengartner

  2. Laboratory of Viral and Molecular Pathogenesis and Laboratory of Molecular Genetics, National Institute of Health, Bethesda, Maryland, 20892, USA

    Jasemine Chambers & Heinz Arnheiter

  3. Bookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York, 10029, USA

    Robert A. Lazzarini

Authors
  1. Rolf M. Zinkernagel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suzanne Cooper
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jasemine Chambers
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert A. Lazzarini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hans Hengartner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Heinz Arnheiter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zinkernagel, R., Cooper, S., Chambers, J. et al. Virus-induced autoantibody response to a transgenic viral antigen. Nature 345, 68–71 (1990). https://doi.org/10.1038/345068a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/345068a0

  • Springer Nature Limited

This article is cited by

Search

Navigation