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β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

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Abstract

Mice homozygous for a β2-microglobulin gene disruption do not express any detectable β2-ITL protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of γδ, CD4+8+ and CD4+8− cells, but have no mature CD4−8+ cells and are defective in CD4−8+ cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor αβ+ CD4−8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules.

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Author notes

  1. Mark Bix and David H. Raulet: Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA

Authors and Affiliations

  1. Whitehead Institute for Biomedicai Research, Nine Cambridge Center, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA

    Maarten Zijlstra, Mark Bix, Neil E. Simister, Janet M. Loring, David H. Raulet & Rudolf Jaenisch

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  1. Maarten Zijlstra
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  2. Mark Bix
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  3. Neil E. Simister
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  4. Janet M. Loring
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  5. David H. Raulet
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  6. Rudolf Jaenisch
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Zijlstra, M., Bix, M., Simister, N. et al. β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells. Nature 344, 742–746 (1990). https://doi.org/10.1038/344742a0

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