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Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

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Abstract

The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.

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Author notes

  1. Edorado Boncinelli: International Institute of Genetics and Biophysics, Via Guglielmo, Marconi 10, 80125 Naples, Italy

Authors and Affiliations

  1. Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    David G. Wilkinson, Sangita Bhatt, Martyn Cook, Edorado Boncinelli & Robb Krumlauf

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  1. David G. Wilkinson
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  2. Sangita Bhatt
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  3. Martyn Cook
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  4. Edorado Boncinelli
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  5. Robb Krumlauf
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Wilkinson, D., Bhatt, S., Cook, M. et al. Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 341, 405–409 (1989). https://doi.org/10.1038/341405a0

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