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Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

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Abstract

The expression of theXenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. Different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. These factors and homoeobox genes thus form part of the mechanism necessary for establishing antero-posterior polarity in the frog embryo.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    A. Ruiz i Altaba & D. A. Melton

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  1. A. Ruiz i Altaba
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  2. D. A. Melton
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i Altaba, A., Melton, D. Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. Nature 341, 33–38 (1989). https://doi.org/10.1038/341033a0

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