Abstract
THE single-headed myosins called myosin-I were first isolated from the protozoan Acanthamoeba1 and subsequently identified in other cells (reviewed in ref. 2). We previously reported evidence that myosin-I is responsible for the movement of membranes, extracted from Acanthamoeba, along actin filaments in vitro3. Here we show for the first time that myosin-I can bind directly to NaOH-extracted membranes isolated from Acanthamoeba and to vesicles of pure lipids with an affinity sufficient for extensive binding in the cell. Membrane-bound myosin-I may provide a mechanism for many cellular movements previously thought to involve filamentous myosin-II.
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Adams, R., Pollard, T. Binding of myosin I to membrane lipids. Nature 340, 565–568 (1989). https://doi.org/10.1038/340565a0
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DOI: https://doi.org/10.1038/340565a0
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