Skip to main content
SpringerLink
Log in

Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Nanometre-level analyses of the movements of membrane glycoproteins tagged with gold particles demonstrate that diffusing particles are not under the influence of a lipid flow, although a subset of particles which appear attached to the cyto-skeleton are moving rearward.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bretscher, M. S. Science 224, 681–686 (1984).

    Article  ADS  CAS  Google Scholar 

  2. Singer, S. J. & Kupfer, A. A. Rev. Cell Biol. 2, 337–365 (1986).

    Article  CAS  Google Scholar 

  3. Bray, D. & White, J. G. Science 239, 883–888 (1988).

    Article  ADS  CAS  Google Scholar 

  4. Forscher, P. & Smith, S. J. J. Cell Biol. 107, 1505–1516 (1988).

    Article  CAS  Google Scholar 

  5. Fisher, G. W., Conrad, P. A., DeBiasio, R. L. & Taylor, D. L. Cell Motil. Cyto. 11, 235–247 (1988).

    Article  CAS  Google Scholar 

  6. Wang, J.-L. J. Cell Biol. 101, 597–602 (1986).

    Article  Google Scholar 

  7. Henis, Y. I. & Elson, E. L. Expl Cell Res. 136, 189–201 (1981).

    Article  CAS  Google Scholar 

  8. Jacobson, K., Ishihara, A. & Inman, R. A. Rev. Physiol. 49, 163–175 (1987).

    Article  CAS  Google Scholar 

  9. Sheetz, M. P. Sem. Hematol. 20, 175–188 (1983).

    CAS  Google Scholar 

  10. Abercrombie, M., Heaysman, S. E. M. & Pegrum, S. M. Expl Cell Res. 62, 389–398 (1970).

    Article  CAS  Google Scholar 

  11. Harris, A. K. in Locomotion of Tissue Cells. Ciba Fdn Symp. 14(d) 3–20 (1973).

    Google Scholar 

  12. Dembo, M. & Harris, A. K. J. Cell Biol. 91, 528–536 (1981).

    Article  CAS  Google Scholar 

  13. Allen, R. D., Allen, N. S. & Travis, J. L. Cell Motil. 1, 291–302 (1981).

    Article  CAS  Google Scholar 

  14. Inouye, S. J. Cell Biol. 89, 346–356 (1981).

    Article  Google Scholar 

  15. Gelles, J., Schnapp, B. J. & Sheetz, M. P. Nature 331, 450–453 (1988).

    Article  ADS  CAS  Google Scholar 

  16. Schroer, T. A. & Sheetz, M. P. Cell, in the press.

  17. Vale, R. D. A. Rev. Cell Biol. 3, 347–378 (1987).

    Article  CAS  Google Scholar 

  18. Saffman, P. G. & Delbruck, M. Proc. natn. Acad. Sci. U.S.A. 72, 3111–3115 (1975).

    Article  ADS  CAS  Google Scholar 

  19. Kucik, D. F., Elson, E. L. & Sheetz, M. P. Nature, 340, 315–317 (1989).

    Article  ADS  CAS  Google Scholar 

  20. Edidin, M. & Zuniga, M. J. Cell Biol. 99, 2333–2335 (1984).

    Article  CAS  Google Scholar 

  21. Livneh, E. J. Cell Biol. 103, 327–331 (1986).

    Article  CAS  Google Scholar 

  22. Scullion, B. F., Hou, Y., Puddington, L., Rose, J. K. & Jacobson, K. J. J. Cell Biol. 105, 69–75 (1987).

    Article  CAS  Google Scholar 

  23. Mitchison, T. & Kirschner, M. Neuron 1, 761–772 (1988).

    Article  CAS  Google Scholar 

  24. Smith, S. J. Science 242, 708–715 (1988).

    Article  ADS  CAS  Google Scholar 

  25. Ishihara, A., Holifield, B. & Jacobson, K. J. Cell Biol. 106, 329–343 (1988).

    Article  CAS  Google Scholar 

  26. Bretscher, M. S. J. Cell Biol. 106, 235–237 (1988).

    Article  CAS  Google Scholar 

  27. Schnapp, B. J. Meth. Enzym. 134, 561–573 (1986).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri, 63110, USA

    Michael P. Sheetz & Stephen Turney

  2. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri, 63110, USA

    Hong Qian & Elliot L. Elson

Authors
  1. Michael P. Sheetz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen Turney
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hong Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elliot L. Elson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sheetz, M., Turney, S., Qian, H. et al. Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements. Nature 340, 284–288 (1989). https://doi.org/10.1038/340284a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/340284a0

  • Springer Nature Limited

This article is cited by

Search

Navigation