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Replicatable RNA reporters

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Elusive infectious agents such as HIV-1 can be detected by nucleic acid hybridization using special probes that are amplified by the enzyme Q-beta replicase as much as a thousand million-fold.

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Authors and Affiliations

  1. Department of Molecular Genetics, Public Health Research Institute, 455 First Avenue, New York, New York, 10016, USA

    F. R. Kramer

  2. Centro de Investigacion sobre Ingenieria Genetica y Biotecnologia, Universidad Nacional Autonoma de Mexico, Apartado Postal 510-3, 62270, Cuernavaca, Morelos, Mexico

    P. M. Lizardi

Authors
  1. F. R. Kramer
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  2. P. M. Lizardi
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Kramer, F., Lizardi, P. Replicatable RNA reporters. Nature 339, 401–402 (1989). https://doi.org/10.1038/339401a0

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