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A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction

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Abstract

A striking example of topographic specificity in synapse formation is the preferential reinnervation of original synaptic sites on denervated muscle fibres by regenerating motor axons. This specificity is mediated by the basal lamina of the synaptic cleft. A glycoprotein, s-laminin, has now been iden-tified that is selectively associated with synaptic basal lamina and is recognized by motoneurons. Molecular cloning reveals that s-laminin is a novel homologue of laminin, a potent promoter of neurite outgrowth.

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Authors and Affiliations

  1. Departments of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA

    Dale D. Hunter & Joshua R. Sanes

  2. Department of Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA

    Vandana Shah & John P. Merlie

Authors
  1. Dale D. Hunter
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  2. Vandana Shah
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  3. John P. Merlie
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  4. Joshua R. Sanes
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Hunter, D., Shah, V., Merlie, J. et al. A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction. Nature 338, 229–234 (1989). https://doi.org/10.1038/338229a0

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