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A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons

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Abstract

Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) in Caenorhabditis elegans. Some of these genes affect only one HSN trait, demonstrating that HSN migration, axonal outgrowth and serotonin expression are mutually independent events in HSN development', others, some of which are regulatory, affect multiple HSN traits. Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types.

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Author notes

  1. Steven L. Mclntire: Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Room 56–623, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA

    Chand Desai, Gian Garriga, Steven L. Mclntire & H. Robert Horvitz

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  1. Chand Desai
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  2. Gian Garriga
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  3. Steven L. Mclntire
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  4. H. Robert Horvitz
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Desai, C., Garriga, G., Mclntire, S. et al. A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638–646 (1988). https://doi.org/10.1038/336638a0

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  • DOI: https://doi.org/10.1038/336638a0

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