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Information value of the rodent bioassay

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Tests for human carcinogens using lifetime rodent bioassays are expensive, time-consuming and give uncertain results. For most chemicals such tests are not cost-effective.

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Author information

Authors and Affiliations

  1. Graduate School of Industrial Administration, Carnegie-Mellon University, Pittsburgh, Pennsylvania, 15213, USA

    Lester B. Lave

  2. Department of Environmental Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    Fanny K. Ennever & Herbert S. Rosenkranz

  3. School of Public Health and Community Medicine, and Dana Program in Genetics and Environmental Health, University of Washington, Seattle, Washington, 98195, USA

    Gilbert S. Omenn

Authors
  1. Lester B. Lave
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  2. Fanny K. Ennever
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  3. Herbert S. Rosenkranz
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  4. Gilbert S. Omenn
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Lave, L., Ennever, F., Rosenkranz, H. et al. Information value of the rodent bioassay. Nature 336, 631–633 (1988). https://doi.org/10.1038/336631a0

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