Abstract
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H–2Db-restricted CD4–8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8– or CD4–8+ mature T cells.
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Teh, H., Kisielow, P., Scott, B. et al. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335, 229–233 (1988). https://doi.org/10.1038/335229a0
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DOI: https://doi.org/10.1038/335229a0
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