Skip to main content
SpringerLink
Log in

A human retinoic acid receptor which belongs to the family of nuclear receptors

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

A cDNA encoding a protein that binds retinoic acid with high affinity has been cloned. The protein is homologous to the receptors for steroid hormones, thyroid hormones and vitamin D3, and appears to be a retinoic acid-inducible {Tans-acting enhancer factor, suggesting that the molecular mechanisms of the effect ofretinoids (vitamin A) on embryonic development, differentiation and tumour cell growth are similar to those described for other members of this nuclear receptor family.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. 1. Lotan, R. Biochim. Biophys. Ada 605, 33-91 (1980). 2. Chytil, F. Pharmacol. Rev. 36, 935-1005 (1984). 3. Roberts, A. B. & Sporn, M. B. in The Retinoids (eds Sporn, M. B., Roberts, A. B. & Goodman, D. S.) 209-286 (Academic, Florida, 1984). 4. Strickland, S. et al Cancer Res. 43, 5268-5272 (1983). 5. Shubeita, H. E., Sambrook, J. F. & McCormick, A. M. Proc. natn. Acad. Sci. U.S.A. 84, 5645-5649 (1987). 6. Haussler, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5525-5529 (1983). 7. Porter, S. B., Ong, D. E., Chytil, F. & Orgebin-Crist, M.-C. / Androl. 6, 197-212 (1985). 8. Maden, M. Trends Genet. 1, 103-107 (1985). 9. Maden, M. & Summerbell, D. J. Embryol. exp. Morph. 97, 239-250 (1986). 10. Thaller, C. & Eichele, G. Nature 327, 625-628 (1987). 38. 11. Wilde, S. M., Wedden, S. E. & Tickle, C. Development 100, 723-733 (1987). 12. Slack, J. M. W. Nature 327, 553-554 (1987). 13. Kurkinen, M., Barlow, D. P., Helfman, D. M., Williams, J. G. & Hogan, B. L. M. Nucleic Acids Res. 11, 6199-6209 (1983). 14. Williams, J. B. & Napoli, J. L. Proc. natn. Acad. Sci. U.S.A. 82, 4658-4662 (1985). 15. Wang, S.-Y., LaRosa, G. J. & Gudas, L. J. Devl Biol. 107, 75-86 (1985). 16. Alonso, A., Weber, T. & Jorcano, J. L. Roux's Arch. Devl. Biol. 196, 16-21 (1987). 17. Green, S. & Chambon, P. Nature 324, 615-617 (1986). 18. Barkai, U. & Sherman, M. I. J. Cell Biol. 104, 671-678 (1987). 19. Ong, D. E., Crow, J. A. & Chytil, F. /. bioL Chem. 257, 13385-13389 (1982). 20. Grippo, J. F. & Gudas, L. J. J. biol Chem. 262, 4492-4500 (1987). 21. Kato, M., Kato, K., Blaner, W. S., Chertow, B. S. & Goodman, D. S. Proc. natn. Acad. Sci. U.S.A. 82, 2488-2492(1985). 22. Wei, L. N., Mertz, J. R., Goodman, D. S. & Nguyen-Hu, M. C. Molec. Endocrin. 1, 526-534 50. (1987). 23. Takase, S., Ong, D. E. & Chytil, F. Arch. Biochem. Biophys. 247, 328-334 (1986). 24. Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Nature 318, 670-672 53. (1985). 25. Green, S. et al. Nature 320, 134-139 (1986). 26. Krust, A. et al. EMBO J. 5, 891-897 (1986). 27. Weinberger, C. et al. Nature 324, 641-646 (1986). 28. Thompson, C. C., Weinberger, C., Lebo, R. & Evans, R. M. Science 237, 1610-1614 (1987). 29. McDonnnell, D. P., Mangelsdorf, D.J., Pike, J. W., Haussler, M. R. & O'Malley, B. W. Science 235, 1214-1217 (1987). 30. Arriza, J. L. et al. Science 237, 268-275 (1987). 31. Green, S. & Chambon, P. Nature 325, 75-78 (1987). 32. Kumar, V. et al. Cell (in the press). 33. Enver, T. Nature 317, 385-386 (1985). 34. Green, S., Gronemeyer, H. & Chambon, P. in Growth Factors and Oncogenes in Breast Cancer (ed. Sluyser, M.) 7-28 (Horwood, Chichester, 1987). 35. Kumar, V., Green, S., Staub, A. & Chambon, P. EMBO J. 5, 2231-2236 (1986). 36. Gronemeyer, H. et al. EMBO J. (in the press). 37. Lacroix, A. & Lippman, M. E. J. din. Invest. 65, 586-591 (1980). 38. Ueda, H., Ono, M., Hagino, Y. & Kuwano, M. Cancer Res. 45, 3332-3338 (1985). 39. Govindan, M. V., Devic, M., Green, S., Gronemeyer, H. & Chambon, P. Nucleic Acids Res. 13,8293-8304(1985). 40. Hollenberg, S. M. et al. Nature 318, 635-641 (1985). 41. Misrahi, M. et al. Biochem. biophys. Res. Comm. 143, 740-748 (1987). 42. Hollenberg, S. M., Giguere, V., Segui, P. & Evans, R. M. Cell 49, 39-46 (1987). 43. Rusconi, S. & Yamamoto, K. R. EMBO J. 6, 1309-1315 (1987). 44. Dejean, A., Bougueleret, L., Grzeschik, K. H. & Tiollais, P. Nature 322, 70-72 (1986). 45. Jeltsch, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 83, 5424-5428 (1986). 46. Zahraoui, A. & Cuny, G. Eur. J. Biochem. 166, 63-69 (1987). 47. Mattei, M. G., Mattei, J. F., Petkovich, M. & Chambon, P. Hum. Genet, (submitted). 48. Gosden, J. R., Middleton, P. G., Rout, D. & De Angelis, C. Cytogenet. Cell Genet. 43, 150-153 (1986). 49. Jansson, M., Philipson, L. & Vennstromm, B. EMBO J. 2, 561-565 (1983). 50. Jetten, A. & De Luca, L. M. Biochem. biophys. Res. Comm. 114, 593-599 (1983). 51. McCue, P. A., Matthaei, K. I., Taketo, M. & Sherman, M. I. Devl Biol. 96, 416-426 (1983). 52. Wang, S.-Y. & Gudas, L. J. J. biol. Chem. 259, 5899-5906 (1984). 53. Lotan, R., Stolarsky, T. & Lotan, D. Cancer Res. 43, 2868-2875 (1983). 54. Debuire, B. et al. Science 224, 1456-1459 (1984). 55. Miesfeld, R. et al. Cell 46, 389-399 (1986). 56. Dente, L., Cesareni, G. & Cortese, R. Nucleic Acids Res. 11, 1645-1655 (1983). 57. Lin, H.-C., Lei, S.-P. & Wilcox, G. Analyt. Biochem. 147, 114-119 (1985).

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologic Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, 11 rue Humann, 67085, Strasbourg-Cédex, France

    Martin Petkovich, Nigel J. Brand, Andrée Krust & Pierre Chambon

Authors
  1. Martin Petkovich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nigel J. Brand
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andrée Krust
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pierre Chambon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petkovich, M., Brand, N., Krust, A. et al. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330, 444–450 (1987). https://doi.org/10.1038/330444a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/330444a0

  • Springer Nature Limited

This article is cited by

Search

Navigation