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HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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Abstract

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles ofHLA-DQβ determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the β-chain, specifies the autoimmune response against the insulin-producing islet cells.

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Author notes

  1. John I. Bell

    Present address: University of Oxford, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK

Authors and Affiliations

  1. Departments of Medical Microbiology and Medicine, D-345 Fairchild Building, Stanford University School of Medicine, Stanford, California, 94305, USA

    John A. Todd, John I. Bell & Hugh O. McDevitt

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Todd, J., Bell, J. & McDevitt, H. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329, 599–604 (1987). https://doi.org/10.1038/329599a0

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