Abstract
Alterations in neuronal gene expression have been proposed to account for permanent changes in brain function such as learning and memory1–4. In particular, it has been suggested that proto-oncogenes such as c-fos (ref. 5) may be rapidly induced in conditions that lead to neuronal plasticity and evoke permanent changes in the expression of effector genes1. Concentrations of the c-fos proto-oncogene increase rapidly following depolarization-induced calcium influx in non-dividing neuronally differentiated PC 12 cells2,3. Recently, the presence and induction of c-fos in the adult brain and spinal cord has been observed6–8. Here we report that electrically-induced seizure activity, which leads to a permanent increase in the response of the brain to future seizures (kindling9), rapidly and transiently increases c-fos protein-like immunoreac-tivity in the nuclei of granule cells in the rat dentate gyrus. These results suggest that c-fos protein is present within the nuclei of adult mammalian neurons, and could be involved in plastic changes in the nervous system associated with seizure activity.
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References
Goelet, P., Castellucci, V. F., Schacher, S. & Kandel E. R. Nature 322, 419–422 (1986).
Greenberg, M. E., Ziff, E. B. & Greene, L. A. Science 234, 80–83 (1986).
Morgan, J. I. & Curran, T. Nature 322, 552–555 (1986).
Montarolo, P. G. et al. Science 234, 1429–1254 (1986).
Bishop, J. M. A. Rev. Biochem. 53, 301–354 (1983).
Dragunow, M., Peterson, M. R. & Robertson, H. A. Eur. J. Pharmac. 135, 113–114 (1987).
Morgan, J. I., Cohen, D. R., Hempstead, J. L. & Curran, T. Science 237, 192–197 (1987).
Hunt, S. P., Pini, A. & Evan, G. Nature 328, 632–635 (1987).
Goddard, G. V. Nature 214, 1020–1021 (1967).
Dragunow, M. Neurosci. Lett. 74, 320–324 (1987).
Curran, T., Van Beveren, C., Ling, N. & Verma, I. M. Molec. cell. Biol. 5, 167–172 (1985).
Adamson, E. D., Meek, J. & Edwards, S. A. EMBO J. 4, 941–947 (1985).
Sambucetti, L. C. & Curran, T. Science 234, 1417–1419 (1986).
Kruijer, W., Cooper, J. A., Hunter, T. & Verma, I. M. Nature 312, 711–716 (1984).
Wong, R. K. S. & Prince, D. A. Brain Res. 234, 385–390 (1978).
Cortes, R., Supavilai, P., Karobath, M. & Palacios, J. M. J. neural Trans. 60, 169–197 (1984).
Paxinos, G. & Watson, C. in The Rat Brain in Stereotaxic Coordinates (Academic, Sydney, 1982).
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Dragunow, M., Robertson, H. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus. Nature 329, 441–442 (1987). https://doi.org/10.1038/329441a0
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DOI: https://doi.org/10.1038/329441a0
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