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The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

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Abstract

We have cloned and sequenced cDNAs of the strychnine-binding subunit of the rat glycine receptor, a neurotransmitter-gated chloride channel protein of the CNS. The deduced polypeptide shows significant structural and amino-acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that there is a family of genes encoding neurotransmitter-gated ion channels.

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Author notes

  1. Christoph Methfessel

    Present address: Bayer AG, D-5090, Leverkusen, FRG

  2. Monika Zensen

    Present address: Max-Planck-Institut für Psychiatric, D-8033, Martinsried, FRG

  3. Konrad Beyreuther

    Present address: Zentrum für Molekulare Biologic, Universität Heidelberg, D-6900, Heidelberg, FRG

Authors and Affiliations

  1. Zentrum für Molekulare Biologic, Universität Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, FRG

    Gabriele Grenningloh, Axel Rienitz, Bertram Schmitt & Eckart D. Gundelfinger

  2. Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-3400, Göttingen, FRG

    Christoph Methfessel

  3. Institut für Genetik, Universität zu Köln, Weyertal 121, D-5000, Köln, 41, FRG

    Monika Zensen & Konrad Beyreuther

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  1. Gabriele Grenningloh
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Grenningloh, G., Rienitz, A., Schmitt, B. et al. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328, 215–220 (1987). https://doi.org/10.1038/328215a0

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