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Highly potent and selective ligands for histamine H3-receptors

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Abstract

New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control ofhistamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provide new tools for affecting physiological and possibly pathological conditions in which histamine is involved.

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Authors and Affiliations

  1. Unite 109 de Neurobiologie et Pharmacologie, Centre Paul Broca de 1'INSERM, 2ter rue d'Alésia, 75014, Paris, France

    J.-M. Arrang, M. Garbarg, H. Pollard & J.-C. Schwartz

  2. Laboratoire de Pharmacie Chimique, UER des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen, France

    J.-C. Lancelo & M. Robba

  3. Laboratoire Bioprojet, 30 rue des Francs Bourgeois, 75003, Paris, France

    J.-M. Lecomte

  4. Institut für Pharmazie, Freie Universität Berlin, Konigin-Luise-Strasse 2 + 4, D-1000, Berlin, FRG

    W. Schunack

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  1. J.-M. Arrang
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  2. M. Garbarg
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  3. J.-C. Lancelo
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  4. J.-M. Lecomte
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  5. H. Pollard
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  6. M. Robba
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  7. W. Schunack
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  8. J.-C. Schwartz
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Arrang, JM., Garbarg, M., Lancelo, JC. et al. Highly potent and selective ligands for histamine H3-receptors. Nature 327, 117–123 (1987). https://doi.org/10.1038/327117a0

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