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Bipolar affective disorders linked to DNA markers on chromosome 11

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Abstract

An analysis of the segregation of restriction fragment length polymorphisms in an Old Order Amish pedigree has made it possible to localize a dominant gene conferring a strong predisposition to manic depressive disease to the tip of the short arm of chromosome 11.

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Author notes

  1. Daniela S. Gerhard

    Present address: Department of Genetics, Washington University School of Medicine, St Louis, Missouri, 63110, USA

Authors and Affiliations

  1. Department of Psychiatry, University of Miami School of Medicine (D-29), PO Box 016960, Miami, Florida, 33101, USA

    Janice A. Egeland, James N. Sussex, Cleona R. Alien & Abram M. Hostetter

  2. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Daniela S. Gerhard & David E. Housman

  3. Child Study Center and Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    David L. Pauls

  4. Departments of Human Genetics and Psychiatry, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Kenneth K. Kidd

Authors
  1. Janice A. Egeland
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  2. Daniela S. Gerhard
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  3. David L. Pauls
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  4. James N. Sussex
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  5. Kenneth K. Kidd
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  6. Cleona R. Alien
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  7. Abram M. Hostetter
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  8. David E. Housman
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Egeland, J., Gerhard, D., Pauls, D. et al. Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325, 783–787 (1987). https://doi.org/10.1038/325783a0

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  • DOI: https://doi.org/10.1038/325783a0

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