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Communication between segments of DNA during site-specific recombination

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Abstract

Some site-specific recombination systems require the interacting DNA sequences to have a specific relative orientation. This means that DNA segments can sense each other's direction even though they may be separated by many thousands of base pairs. Here, we review the surprising results of recent experiments that lead to a new model which accounts for site orientation specificity and relates it to other recombination systems where relative orientation is not critical.

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Authors and Affiliations

  1. Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Martin Gellert

  2. Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland, 20892, USA

    Howard Nash

Authors
  1. Martin Gellert
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  2. Howard Nash
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Gellert, M., Nash, H. Communication between segments of DNA during site-specific recombination. Nature 325, 401–404 (1987). https://doi.org/10.1038/325401a0

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  • DOI: https://doi.org/10.1038/325401a0

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