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The c-erb-A gene encodes a thyroid hormone receptor

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Abstract

The cDNA sequence of human c-erb-A, the cellular counterpart of the viral oncogene v-erb-A, indicates that the protein encoded by the gene is related to the steroid hormone receptors. Binding studies with the protein show it to be a receptor for thyroid hormones.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, PO Box 85800, San Diego, California, 92138, USA

    Cary Weinberger, Catherine C. Thompson, Estelita S. Ong & Ronald M. Evans

  2. Regulatory Biology Laboratory, The Salk Institute for Biological Studies, PO Box 85800, San Diego, California, 92138, USA

    Donald J. Gruol

  3. Department of Biology, University of California, San Diego, California, 92093, USA

    Catherine C. Thompson

  4. Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, California, 94143, USA

    Roger Lebo

Authors
  1. Cary Weinberger
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  2. Catherine C. Thompson
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  3. Estelita S. Ong
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  4. Roger Lebo
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  5. Donald J. Gruol
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  6. Ronald M. Evans
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Weinberger, C., Thompson, C., Ong, E. et al. The c-erb-A gene encodes a thyroid hormone receptor. Nature 324, 641–646 (1986). https://doi.org/10.1038/324641a0

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  • DOI: https://doi.org/10.1038/324641a0

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