Abstract
Voltage-sensitive dyes allow neuronal activity to be studied by non-invasive optical techniques. They provide an attractive means of investigating striate cortex, where important response properties are organized in two dimensions. In the present study, patterns of ocular dominance and orientation selectivity were obtained repeatedly from the same patch of cortex using the dye merocyanine oxazolone, together with current image-processing techniques. The patterns observed agree with most established features of monkey striate cortex and suggest a new unit of cortical organization; one that is modular in structure and which appears to link the organization of orientation selectivity with that of ocular dominance.
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References
Hubel, D. H. & Wiesel, T. N. J. Physiol., Lond. 160, 106–154 (1962).
Hubel, D. H. & Wiesel, T. N. J. Neurophysiol. 28, 229–289 (1965).
Hubel, D. H. & Wiesel, T. N. J. Physiol., Lond. 195, 215–243 (1968).
Hubel, D. H. & Wiesel, T. N. Nature 225, 41–42 (1970).
Hubel, D. H. & Wiesel, T. N. J. comp. Neurol. 146, 421–450 (1972).
Hubel, D. H. & Wiesel, T. N. J. comp. Neurol. 158, 295–306 (1974).
Hubel, D. H. & Wiesel, T. N. J. comp. Neurol. 158, 267–294 (1974).
Hubel, D. H. & Wiesel, T. N. Proc. R. Soc. B198, 1–59 (1977).
LeVay, S., Hubel, D. H. & Wiesel, T. N. J. comp. Neurol. 159, 559–576 (1975).
Fitzpatrick, D., Lund, J. S. & Blasdel, G. J. Neurosci. 5, 3329–3349 (1984).
Sillito, A. M. in Cerebral Cortex Vol. 2 (eds Jones, E. G. & Peters, A.) 91–118 (Plenum, New York, 1984).
Hubel, D. H., Wiesel, T. N. & Stryker, M. J. comp. Neurol. 177, 361–380 (1978).
Horton, C. H. & Hubel, D. H. Nature 292, 762–764 (1981).
Humphrey, A. L. & Hendrickson, A. E. J. Neurosci. 3, 345–358 (1983).
Livingstone, M. S. & Hubel, D. H. J. Neurosci. 4(1), 309–356 (1984).
Davila, H. V., Salzberg, B. M., Cohen, L. B. & Waggoner, A. S. Nature new Biol. 241, 159–161 (1973).
Salzberg, B. M., Davila, H. V. & Cohen, L. B. Nature 246, 508–509 (1973).
Cohen, L. B. et al. J. Membrane Biol. 19, 1–360 (1974).
Ross, W. N. et al. J. Membrane Biol. 33, 141–183 (1977).
Morad, M. & Salama, G. J. Physiol., Lond. 292, 267–295 (1979).
Cohen, L. B. & Salzberg, B. M. Rev. Physiol. Biochem. Pharmac. 83, 35–83 (1978).
Salzberg, B. M. Curr. Meth. cell. Neurobiol. 3, 139–187 (1983).
Orbach, H. S., Cohen, L. B. & Grinvald, A. J. Neurosci. 5, 185–195 (1985).
Salzberg, B. M., Grinvald, A., Cohen, L. B., Davila, H. V. & Ross, W. N. J. Neurosci. 40, 1281–1286 (1977).
Grinvald, A., Cohen, L. B., Lesher, S. & Boyle, M. B. J. Neurophysiol. 45, 829–840 (1981).
Salama, G., Sanger, T. & Cohen, L. B. Biol. Bull. 161, 316 (1981).
Blasdel, G. G. & Fitzpatrick, D. J. Neurosci. 4, 880–895 (1984).
Sokoloff, L. CIBA Fdn Symp. 56, 171–197 (1978).
Kelley, J. P. & Van Essen, D. C. J. Physiol., Lond. 238, 515–574 (1974).
Ross, W. N. & Reichardt, L. F. J. Membrane Biol. 48, 343–356 (1979).
Nakajima, S. & Gilai, A. J. gen. Physiol. 76, 729–750 (1980).
Heiny, J. A. & Vergara, J. J. gen. Physiol. 85, 805–837 (1984).
Braitenberg, V & Braitenberg, C. Biol. Cybernet. 33, 179–186 (1979).
Rockland, K. S. & Lund, J. S. J. comp. Neurol. 216, 303–313 (1983).
Livingstone, M. S. & Hubel, D. H. J. Neurosci. 4, 2830–2835 (1984).
Wong-Riley, M. Brain Res. 162, 201–217 (1979).
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Blasdel, G., Salama, G. Voltage-sensitive dyes reveal a modular organization in monkey striate cortex. Nature 321, 579–585 (1986). https://doi.org/10.1038/321579a0
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DOI: https://doi.org/10.1038/321579a0
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