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Imprinting and colorectal cancer

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Abstract

Loss of imprinting in normal colon mucosa may be a valuable marker for identifying a subgroup of individuals at risk for developing sporadic colorectal cancer ( pages 1276–1280 ).

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References

  1. Cui, H., Horon, I.L., Ohlsson, R., Hamilton, S.R. & Feinberg A.P. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nature Med. 4, 1276–1280 (1998).

    Article  CAS  Google Scholar 

  2. Rainier, S. et al. Relaxation of imprinted genes in human cancer. Nature 362, 747–749 ( 1993).

    Article  CAS  Google Scholar 

  3. Ogawa, O. et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumor. Nature 362, 749– 751 (1993).

    Article  CAS  Google Scholar 

  4. Kinouchi, Y. et al. Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer. Cancer Lett. 107, 105–108 (1996).

    Article  CAS  Google Scholar 

  5. Okamoto, K., Morison, I.M., Taniguchi, T. & Reeve A.E. Epigenetic change at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms' tumorigenesis. Proc. Natl. Acad. Sci. USA 94, 5367–5371 (1997).

    Article  CAS  Google Scholar 

  6. Herman, J.G. et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95, 6870–6875 (1998).

    Article  CAS  Google Scholar 

  7. Steeman, M.J.C. et al. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumor. Nature Genet. 7, 433–439 (1994).

    Article  Google Scholar 

  8. Jones, B.K., Levorse, J.M. & Tilghman S.M. Igf2 imprinting does not require its own DNA methylation or H19 RNA. Genes Dev. 12, 2200– 2207 (1998).

    Article  CAS  Google Scholar 

  9. Ahuja, N. et al. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res. 57, 3370–3374 (1997).

    CAS  PubMed  Google Scholar 

  10. Herman, J.G., Graff J.R., Myohanen, S, Nelkin, B.D. & Baylin S.B. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93 , 9821–9826 (1996).

    Article  CAS  Google Scholar 

  11. Silva, A.J. & White, R. Inheritance of allelic blueprints for methylation patterns. Cell 54, 145– 152 (1998).

    Article  Google Scholar 

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Authors and Affiliations

  1. Hereditary Tumor Research Project Tokyo Metropolitan Komagome Hospital, Tokyo, 113-8677, Japan

    Michiko Miyaki

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  1. Michiko Miyaki
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Miyaki, M. Imprinting and colorectal cancer. Nat Med 4, 1236–1237 (1998). https://doi.org/10.1038/3214

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