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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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Abstract

Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

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Authors and Affiliations

  1. Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, 3050, Australia

    J. M. Adams, A. W. Harris, L. M. Corcoran, W. S. Alexander & S. Cory

  2. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    C. A. Pinkert & R. L. Brinster

  3. Howard Hughes Medical Institute, University of Washington, Seattle, Washington, 98195, USA

    R. D. Palmiter

Authors
  1. J. M. Adams
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  2. A. W. Harris
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  3. C. A. Pinkert
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  4. L. M. Corcoran
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  5. W. S. Alexander
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  6. S. Cory
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  7. R. D. Palmiter
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  8. R. L. Brinster
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Adams, J., Harris, A., Pinkert, C. et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318, 533–538 (1985). https://doi.org/10.1038/318533a0

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  • DOI: https://doi.org/10.1038/318533a0

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