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Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

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Abstract

We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.

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Author notes

  1. P. A. Stadler: Deceased.

Authors and Affiliations

  1. Preclinical Research Department, Sandoz Ltd, CH-4002, Basel, Switzerland

    B. P. Richardson, G. Engel, P. Donatsch & P. A. Stadler

Authors
  1. B. P. Richardson
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  2. G. Engel
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  3. P. Donatsch
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  4. P. A. Stadler
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Richardson, B., Engel, G., Donatsch, P. et al. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316, 126–131 (1985). https://doi.org/10.1038/316126a0

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  • DOI: https://doi.org/10.1038/316126a0

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