Skip to main content

Advertisement

SpringerLink
Log in

A viral enhancer element specifically active in human haematopoietic cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

One particular class of DNA regulatory elements, the enhancers or activators, can, relatively independently of distance and orientation, dramatically increase the transcriptional activity of homologous and heterologous promoters located in cis (see refs 1–3 for reviews, also refs 4–6). Sequence differences between various heterologous enhancers7,8 may explain their apparent host-and/or tissue-specific action9–15. Furthermore, differences in the transcriptional control elements may contribute to viral tropism. At least for murine leukaemia virus isolates, thymotropism and leukaemogenicity have been attributed to alterations within the viral long terminal repeat15–17, which harbours their enhancers and other transcriptional control elements. We report here the identification of a viral enhancer element possessing a very restricted tissue range. The enhancer is active in all human cells of the haematopoetic system tested, but not in cells of fibroblast or epithelial origin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Khoury, G. & Gruss, P. Cell 33, 313–314 (1983).

    Article  CAS  Google Scholar 

  2. Gruss, P. DNA 2, 50 (1984).

    Google Scholar 

  3. Gluzman, Y. & Shenk, T. (eds) Current Communications in Molecular Biology (Cold Spring Harbor Laboratory, New York, w983).

  4. Banerji, J., Rusconi, S. & Schaffner, W. Cell 27, 299–308 (1981).

    Article  CAS  Google Scholar 

  5. Moreau, P. et al. Nucleic Acids Res. 9, 6047–6068 (1981).

    Article  ADS  CAS  Google Scholar 

  6. Wasylik, B., Wasylyk, C., Augereau, P. & Chambon, P. Cell 32, 503–514 (1983).

    Article  Google Scholar 

  7. Weiher, H., König, M. & Gruss, P. Science 219, 626–631 (1983).

    Article  ADS  CAS  Google Scholar 

  8. Hen, R., Borrelli, E., Sassone-Corsi, P. & Chambon, P. Nucleic Acids Res. 11, 8747–8760 (1983).

    Article  CAS  Google Scholar 

  9. Laimins, L., Khoury, G., Gorman, C., Howard, B. H. & Gruss, P. Proc. natn. Acad. Sci. U.S.A. 79, 6453–6457 (1982).

    Article  ADS  CAS  Google Scholar 

  10. Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).

    Article  CAS  Google Scholar 

  11. De Villiers, J., Olson, L., Tyndall, C. & Schaffner, W. Nucleic Acids Res. 10, 7965–7976 (1982).

    Article  CAS  Google Scholar 

  12. Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).

    Article  CAS  Google Scholar 

  13. Queen, C. & Baltimore, D. Cell 33, 741–748 (1983).

    Article  CAS  Google Scholar 

  14. Picard, D. & Schaffner, W. Nature 307, 80–82 (1984).

    Article  ADS  CAS  Google Scholar 

  15. Lenz, J. et al. Nature 308, 467–470 (1984).

    Article  ADS  CAS  Google Scholar 

  16. De Groseillers, L., Rassart, E. & Jolicoeur, P. Proc. natn. Acad. Sci. U.S.A. 80, 4203–4207 (1983).

    Article  ADS  Google Scholar 

  17. Celander, D. & Haseltine, W. A. Nature 312, 159–162 (1984).

    Article  ADS  CAS  Google Scholar 

  18. Zur Hausen, H. & Gissmann, L. Med. Microbiol. Immun. 167, 137–153 (1979).

    Article  CAS  Google Scholar 

  19. Zur Hausen, H., Gissmann, L., Minecheva, A. & Böcker, J. F. in Viruses in Naturally Occurring Cancers Vol. 7a (eds Essex, M., Todaro, G. & zur Hausen, H.) 365–373 (Cold Spring Harbor Laboratory, New York, 1980).

    Google Scholar 

  20. Brade, L., Vogl, W., Gissmann, L. & zur Hausen, H. Virology 114, 228–235 (1981).

    Article  CAS  Google Scholar 

  21. Takemoto, K. K., Furuno, A., Kato, K. & Yoshiike, K. Virology 42, 502–509 (1982).

    CAS  Google Scholar 

  22. Pawlita, M., Clad, A. & zur Hausen, H. Virology (in the press).

  23. Tooze, J. (ed.) DNA Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1983).

  24. De Villiers, J. & Schaffner, W. Nucleic Acids Res. 9, 6251–6264 (1981).

    Article  CAS  Google Scholar 

  25. Rosenthal, N., Kress, M., Gruss, P. & Khoury, G. Science 222, 749–755 (1983).

    Article  ADS  CAS  Google Scholar 

  26. Gruss, P., Dhar, R. & Khoury, G. Proc. natn. Acad. Sci. U.S.A. 78, 943–947 (1981).

    Article  ADS  CAS  Google Scholar 

  27. Fromm, M. & Berg, P. J. molec. appl. Genet. 1, 457–481 (1982).

    CAS  Google Scholar 

  28. Kenney, S., Natarajan, V., Strike, D., Khoury, G. & Salzman, N. P. Science 226, 1337 (1984).

    Article  ADS  CAS  Google Scholar 

  29. Lusky, M., Berg, L., Weiher, H. & Botchan, M. Molec. cell. Biol. 3, 1108–1122 (1983).

    Article  CAS  Google Scholar 

  30. Gorman, C. M., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044–1051 (1982).

    Article  CAS  Google Scholar 

  31. Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning, 353–354 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  32. Lusky, M. & Botchan, M. Nature 293, 79–81 (1981).

    Article  ADS  CAS  Google Scholar 

  33. Kimura, G. & Dulbecco, R. Virology 49, 394–403 (1972).

    Article  CAS  Google Scholar 

  34. McCutchan, J. H. & Pagano, J. S. J. natn. Cancer Inst. 41, 351 (1965).

    Google Scholar 

  35. Klein, G., Giovanella, B., Westman, A., Stehlin, J. S. & Munford, D. Intervirology 5, 319–334 (1975).

    Article  CAS  Google Scholar 

  36. Minowada, J., Ohnuma, T. & Moore, G. E. J. natn. Cancer Inst. 49, 891–895 (1972).

    CAS  Google Scholar 

  37. Kearney, J. F., Radbruch, A., Liesegang, B. & Rajewski, K. J. Immun. 123, 1548–1550 (1979).

    CAS  Google Scholar 

  38. Takemoto, K. K. & Tadahito, K. J. Virol. 50, 100–105 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Green, M. R., Treisman, R. & Maniatis, T. Cell 35, 137–148 (1983).

    Article  CAS  Google Scholar 

  40. Schöler, H. R. & Gruss, P. Cell 36, 403–411 (1984).

    Article  Google Scholar 

  41. Mercola, M., Goverman, J., Mirell, C. & Calame, K. Science 227, 266–270 (1985).

    Article  ADS  CAS  Google Scholar 

  42. Ephrussi, A., Church, G. M., Tonegawa, S. & Gilbert, W. Science 227, 134–139 (1985).

    Article  ADS  CAS  Google Scholar 

  43. Ziegler, A., Uchanska-Zielger, B., Zeuthen, J. & Wernet, P. Somatic Cell Genet. 8, 775–789 (1982).

    Article  CAS  Google Scholar 

  44. Edwards, P. A. W. Biochem. J. 200, 1–10 (1981).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Michael Pawlita: Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900 Heidelberg, FRG

Authors and Affiliations

  1. Zentrum für Molekulare Biologie, Universität Heidelberg, Im Neuenheimer Feld 364, D-6900, Heidelberg, FRG

    Luitgard Mosthaf, Michael Pawlita & Peter Gruss

Authors
  1. Luitgard Mosthaf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael Pawlita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter Gruss
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mosthaf, L., Pawlita, M. & Gruss, P. A viral enhancer element specifically active in human haematopoietic cells. Nature 315, 597–600 (1985). https://doi.org/10.1038/315597a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/315597a0

  • Springer Nature Limited

This article is cited by

Search

Navigation