Abstract
V5 and V4 are areas of macaque monkey prestriate visual cortex that are specialized for involvement in different aspects of visual perception, namely motion for V5 (refs 1–4) and colour vision, with other possible functions, for V4 (refs 2, 5–9). Thus, it is unlikely that they should be fed the same information for further processing, yet both receive a strong input from patches of the upper layers of V2 (refs 10, 11), the area immediately adjoining the primary visual cortex, V1. V2, however, seems to comprise functionally distinct subregions, which can be revealed by staining the tissue for the mitochondrial enzyme cytochrome oxidase12–15. Here we report that V4 and V5 are connected with separate cytochrome oxidase-defined subregions of V2, suggesting that cortical pathways dealing with motion and colour perception are segregated in their passage through V2, and reinforcing evidence for functional specialization in the visual cortex16–18.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Zeki, S. M. J. Physiol., Lond. 236, 549–573 (1974).
Zeki, S. Proc. R. Soc. B217, 449–470 (1983).
Maunsell, J. H. R. & Van Essen, D. C. J. Neurophysiol. 49, 1127–1147 (1983).
Wurtz, R. H., Richmond, B. J. & Newsome, W. T. in Dynamic Aspects of Neocortical Function (eds Edelman, G. M., Gall, W. E. & Cowan, W. M.) 195–217 (Wiley, New York, 1985).
Zeki, S. M. Brain Res. 53, 422–427 (1973).
Zeki, S. M. Proc. R. Soc. B197, 195–223 (1977).
Andersen, V. O., Guld, C. & Sjö, O. in Colour Vision (ed. Mollon, J. D. & Sharpe, C.) 297–301 (Academic, London, 1983).
Tanaka, M. et al. Neurosci. Lett. Suppl. 18, 571 (1984).
Wild, H. M., Butler, S. R., Carden, D. & Kulikowski, J. J. Nature 313, 133–135 (1985).
Fries, W. & Zeki, S. J. Physiol., Lond. 340, 51P (1983).
Maunsell, J. H. R. & Van Essen, D. C. J. Neurosci. 3, 2563–2586 (1983).
Livingstone, M. S. & Hubel, D. H. Proc. natn. Acad. Sci. U.S.A. 79, 6098–6101 (1982).
Tootel, R. B. H., Silverman, M. S., De Valois, R. L. & Jacobs, G. H. Science 220, 737–739 (1983).
Horton, J. C. Phil. Trans. R. Soc. B304, 199–253 (1984).
Livingstone, M. S. & Hubel, D. H. J. Neurosci. 4, 309–356 (1984).
Zeki, S. M. J. Physiol., Lond. 277, 273–290 (1978).
Zeki, S. M. Nature 274, 423–428 (1978).
Shipp, S. & Zeki, S. J. Physiol., Lond. 353, 23P (1984).
Zeki, S. M. Cold Spring Harb. Symp. quant. Biol. 40, 591–600 (1975).
Zeki, S. M. Brain Res. 14, 271–297 (1969).
Cragg, B. G. Vision Res. 9, 733–747 (1969).
Baizer, J. S., Robinson, D. L. & Dow, B. M. J. Neurophysiol. 40, 1024–1037 (1977).
Zeki, S. M. Brain Res. 34, 19–35 (1971).
Zeki, S. M. Proc. R. Soc. B193, 199–207 (1976).
Gattass, R. & Gross, C. G. J. Neurophysiol. 46, 621–638 (1981).
Wong-Riley, M. Brain Res. 171, 11–28 (1979).
Mesulam, M. M. Tracing Neural Connections with HRP (Wiley, New York, 1982).
Wong-Riley, M. T. T. & Carroll, E. W. J. comp. Neurol. 228, 18–37 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shipp, S., Zeki, S. Segregation of pathways leading from area V2 to areas V4 and V5 of macaque monkey visual cortex. Nature 315, 322–324 (1985). https://doi.org/10.1038/315322a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/315322a0
- Springer Nature Limited
This article is cited by
-
Neural patterns of conscious visual awareness in the Riddoch syndrome
Journal of Neurology (2023)
-
Mapping the primate thalamus: systematic approach to analyze the distribution of subcortical neuromodulatory afferents
Brain Structure and Function (2023)
-
Function-specific projections from V2 to V4 in macaques
Brain Structure and Function (2022)
-
An fMRI study of age-associated changes in basic visual discrimination
Brain Imaging and Behavior (2021)
-
GABAergic and non-GABAergic subpopulations of Kv3.1b-expressing neurons in macaque V2 and MT: laminar distributions and proportion of total neuronal population
Brain Structure and Function (2020)