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An antiemetic is antidotal to the satiety effects of cholecystokinin

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Abstract

Although cholecystokinin (CCK) has been proposed as a satiety agent1–4, this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion5–7. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.

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References

  1. Holt, J., Antin, J., Gibbs, R. C., Young, R. C. & Smith, G. P. Physiol. Behav. 12, 497–498 (1974).

    Article  CAS  Google Scholar 

  2. Gibbs, J. R., Young, R. C. & Smith, G. P. Nature 245, 323–325 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Smith, G. P. et al. Peptides 2, 57–59 (1981).

    Article  CAS  Google Scholar 

  4. Gibbs, J. & Smith, G. P. Nature 285, 592 (1980).

    Article  ADS  Google Scholar 

  5. Deutsch, J. A. & Hardy, W. T. Nature 266, 57–59 (1977).

    Article  Google Scholar 

  6. Swerdlow, N. R. van der Kooy, D., Koob, G. F. & Wenger, J. R. Life Sci. 32, 2087–2093 (1983).

    Article  CAS  Google Scholar 

  7. Deutsch, J. A. Thiel, T. R. & Greenberg, L. H. Behav. Biol. 24, 393–399 (1978).

    Article  CAS  Google Scholar 

  8. Berry, H. & Flower, R. J. Gastroenterology 60, 409–420 (1971).

    CAS  PubMed  Google Scholar 

  9. Ivy, A. C. & Oldberg, E. Am. J. Physiol. 86, 599–613 (1928).

    CAS  Google Scholar 

  10. Coil, J. D., Hankins, W. G., Jenden, D. J. & Garcia, J. Psychopharmacology 56, 21–25 (1978).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, University of California, San Diego, San Diego, California, 92093, USA

    Beth O. Moore & J. A. Deutsch

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  1. Beth O. Moore
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  2. J. A. Deutsch
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Moore, B., Deutsch, J. An antiemetic is antidotal to the satiety effects of cholecystokinin. Nature 315, 321–322 (1985). https://doi.org/10.1038/315321a0

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  • DOI: https://doi.org/10.1038/315321a0

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