Abstract
Two forms of RNA polymerase holoenzyme have been identified in the filamentous differentiating bacterium Streptomyces coelicolor. They contain different species of σ factor and are distinguishable by their ability to recognize different promoter classes. These and other holoenzyme forms may in part determine the selective expression of different gene sets in this morphologically-complex bacterium.
Similar content being viewed by others
References
Chater, K. F. in Microbial Development (eds Losick, R. & Shapiro, L. ) 89–116 (Cold Spring Harbor Laboratory, New York, 1984).
Chater, K. & Hopwood, D. A. in The Biology of the Actinomycetes (eds Goodfellow, M., Mordarski, M. & Williams, S. T. ) 229–286 (Academic, London, 1984).
Losick, R. & Youngman, P. J. in Microbial Development (eds Losick, R. & Shapiro, L.) 63–88 (Cold Spring Harbor Laboratory, New York, 1984).
Doi, R. H. A. Rev. Genet. 11, 29 (1977).
Losick, R. & Pero, J. Cell 25, 582–584 (1981).
Doi, R. H. Archs Biochem. Biophys. 214, 772 (1982).
Moran, C. P., Jr. et al. Molec. gen. Genet. 186, 339–346 (1982).
Haldenwang, W. G. & Losick, R. Proc. natn. Acad. Sci. U.S.A. 77, 7000–7004 (1980).
Johnson, W. C., Moran, C. P., Jr., & Losick, R. Nature 302, 800–804 (1983).
Moran, C. P., Jr., Johnson, W. C. & Losick, R. J. molec. Biol. 162, 709–713 (1982).
Talti, K. M. & Moran, C. P., Jr., J. molec. Biol. 175, 285–297 (1984).
Jones, G. Archs Biochem. Biophys. 198, 195–204 (1979).
Cooper, C. S. & Chater, K. F. A. Rep. John Innes Inst. 66, 83 (1975).
Hager, D. & Burgess, R. Analyt. Biochem. 109, 76–86 (1980).
Robbins, P. W., Wirth, D. F. & Hering, C. J. biol. Chem. 256, 10640–10644 (1981).
Robbins, P. W. et al. J. biol. Chem. 259, 7577–7583 (1984).
Tarentino, A. L. & Maley, F. J. biol. Chem. 249, 811–817 (1974).
Berk, A. J. & Sharp, P. A. Cell 12, 721–732 (1977).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–559 (1980).
Rosenberg, M. & Court, D. A. Rev. Genet. 13, 319–353 (1979).
Landick, R. et al. Cell 38, 175–182 (1984).
Grossman, A. D., Erickson, J. W. & Gross, C. A. Cell 38, 383–390 (1984).
Thompson, D. J., Kieser, T., Ward, J. M. & Hopwood, D. A. Gene 20, 51–62 (1982).
Chater, K. F. & Bruton, C. J. Gene 26, 67–78 (1983).
Malpartida, F. & Hopwood, D. A. Nature 309, 462–464 (1984).
Hoch, J. A., Shiflett, M. A., Trowsdale, J. & Chen, S. M. H. in Spores VII (eds Chambliss, G. and Vary, J. C.) 131–135 (American Society for Microbiology, Washington, D. C. 1978).
Zuber, P. & Losick, R. Cell 35, 275–283 (1983).
Gilman, M. & Chamberlain, M. Cell 35, 284–293 (1983).
Bibb, M. & Cohen, S. N. Mol. gen. Genet. 187, 265–277 (1982).
Jaurin, B. & Cohen, S. N. Gene 28, 83–91 (1984).
Yagi, Y., McLellan, T., Frez, W. & Clewell, D. Antimicrob. Agents Chemother. 13, 884–887 (1978).
Ehrlich, S. D. Proc. natn. Acad. Sci. U.S.A. 74, 1680–1682 (1977).
Kreft, J., Bernhard, K. & Goebel, W. Mol. gen. Genet. 162, 59–67 (1978).
Lee, G. & Pero, J. Mol. gen. Genet. 180, 57–65 (1980).
McLaughlin, J. R., Chang, S-Y. & Chang, S. Nucleic Acids Res. 10, 3905–3919 (1982).
Gray, O. & Chang, S. J. Bacteriol. 145, 422–428 (1981).
Lang, N. thesis, Harvard Univ. (1982).
Banner, C. D. B., Moran, C. P., Jr., & Losick, R. J. molec. Biol. 168, 351–365 (1983).
Thompson, C. J. & Gray, G. S. Proc. natn. Acad. Sci. U.S.A. 80, 5190–5194 (1983).
Shorenstein, R. G. & Losick, R. J. biol. Chem. 17, 6163–6169 (1973).
Penn, M. D., Thireos, G. & Greer, H. Molec. cell. Biol. 4, 520–528 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Westpheling, J., Ranes, M. & Losick, R. RNA polymerase heterogeneity in Streptomyces coelicolor. Nature 313, 22–27 (1985). https://doi.org/10.1038/313022a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/313022a0
- Springer Nature Limited
This article is cited by
-
The physiology and biosynthesis of secondary metabolites
Acta Biologica Hungarica (1997)
-
Isolation of DNA-dependent RNA polymerase from the thermophilic actinomyceteThermomonospora curvata
Folia Microbiologica (1994)
-
Cloning of a Microbispora bispora cellobiohydrolase gene in Streptomyces lividans
Applied Microbiology and Biotechnology (1993)
-
Transcriptional organization and regulation of an antibiotic export complex in the producing Streptomyces culture
Molecular and General Genetics MGG (1991)
-
Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin
Molecular and General Genetics MGG (1991)