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Gene structure of human cardiac hormone precursor, pronatriodilatin

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Abstract

Atrial cardiocytes contain granules typical of protein-secreting cells1, and atrial extracts are known to contain a powerful natriuretic and diuretic activity2 and to possess smooth muscle relaxant activity3. A variety of active atrial peptides have been isolated, including a family of related peptides showing natriuretic, diuretic and smooth muscle relaxant activities in rat4–9 and human atria10; these peptides were named atrial natriuretic factor (ANF). Another unrelated peptide from pig atria11, cardiodilatin, is thought to possess only smooth muscle relaxant activity. Its partial amino acid sequence shows no homology with ANF sequences. The sequence analysis of a large form (106 amino acids) of ANF12 and of ANF complementary DNA clones13–16 indicates that cardiodilatin and ANF peptides are synthesized from a common precursor. This precursor also contains a signal peptide sequence expected of a secretory protein17. We now describe the complete structure and sequence of the human gene for this novel hormone precursor that we call pronatriodilatin12.

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Author notes

  1. Richard A. F. Dixon, Robert A. Zivin and Jon H. Condra: Virus and Cell Biology Research, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486, USA

Authors and Affiliations

  1. Laboratoire de biologie moléculaire, Institut de recherches cliniques de Montréal, 110 ouest, Avenue de Pins, Montréal, Canada, H2W 1R7

    Mona Nemer, Michel Chamberland, Diane Sirois, Stephania Argentin, Jacques Drouin, Richard A. F. Dixon, Robert A. Zivin & Jon H. Condra

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  1. Mona Nemer
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  2. Michel Chamberland
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  3. Diane Sirois
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  4. Stephania Argentin
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  5. Jacques Drouin
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  6. Richard A. F. Dixon
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  7. Robert A. Zivin
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  8. Jon H. Condra
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Nemer, M., Chamberland, M., Sirois, D. et al. Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature 312, 654–656 (1984). https://doi.org/10.1038/312654a0

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