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A novel transforming gene in a human malignant melanoma cell line

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Abstract

Cellular transforming genes can be detected in human tumours by DNA-mediated transfection into NIH 3T3 mouse fibroblasts1,2. The activated transforming genes have been, in most cases, members of the ras gene family, of which the most frequently found is the c-Ki-ras oncogene3–7 and least frequently the c-Ha-ras gene8–10. An increasing number of studies has identified the presence of activated N-ras (which has no known viral homologue) in human tumour cell lines11–18. Furthermore, other transforming genes, distinct from the ras gene family, have been reported in B-and T-cell lymphomas19,20. The activation of c-Ha-ras and N-ras has been described in some cell lines derived from cases of human malignant melanoma21. Here we describe the presence of transforming activity in the DNA from a human melanoma cell line which shows weak homology with members of the ras oncogene family.

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Authors and Affiliations

  1. Marie Curie Memorial Foundation, Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK

    R. A. Padua, N. Barrass & G. A. Currie

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  1. R. A. Padua
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  2. N. Barrass
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  3. G. A. Currie
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Padua, R., Barrass, N. & Currie, G. A novel transforming gene in a human malignant melanoma cell line. Nature 311, 671–673 (1984). https://doi.org/10.1038/311671a0

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