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Molecular cloning of a new transforming gene from a chemically transformed human cell line

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Abstract

Molecular cloning of the transforming gene from a chemically transformed human osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11.4–7qter) and by this criterion and by direct hybridization to be shown to be unrelated to known oncogenes.

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Authors and Affiliations

  1. Laboratory of Molecular Carcinogenesis, Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, USA

    Colin S. Cooper

  2. Laboratory of Molecular Oncology, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Morag Park, Donald G. Blair & Michael A. Tainsky

  3. The Wistar Institute, 36th and Spruce, Philadelphia, Pennsylvania, 19104, USA

    Kay Huebner & Carlo M. Croce

  4. Basic Research Program, Litton Bionetics, Inc., Frederick, Maryland, 21701, USA

    George F. Vande Woude

Authors
  1. Colin S. Cooper
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  2. Morag Park
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  3. Donald G. Blair
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  4. Michael A. Tainsky
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  5. Kay Huebner
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  6. Carlo M. Croce
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  7. George F. Vande Woude
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Cooper, C., Park, M., Blair, D. et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311, 29–33 (1984). https://doi.org/10.1038/311029a0

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  • DOI: https://doi.org/10.1038/311029a0

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