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Functional role for c-myc in mitogenic response to platelet-derived growth factor

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Abstract

In BALB/c-3T3 cells, expression of the c-myc gene is stimulated by platelet-derived growth factor (PDGF). Using mouse mammary tumour virus promoter: c-myc recombinant plasmids, 3T3 sublines were constructed in which hydrocortisone was the primary determinant of myc mRNA content. The c-myc gene product is an intracellular mediator of the growth response to PDGF though probably not the only one. Both the human and the mouse c-myc genes stimulate clonal growth of 3T3 cells in PDGF-free medium suggesting new strategies for analysis of oncogenes which do not function in focus formation assays.

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References

  1. Antoniades, H. N., Scher, C. D. & Stiles, C. D. Proc. natn. Acad. Sci. U.S.A. 76, 1809–1813 (1979).

    Article  ADS  CAS  Google Scholar 

  2. Heldin, C. H., Westermark, B. & Wasteson, A. Proc. natn. Acad. Sci. U.S.A. 76, 3722–3726 (1979).

    Article  ADS  CAS  Google Scholar 

  3. Deuel, T. et al. J. biol. Chem. 256, 8896–8899 (1981).

    CAS  PubMed  Google Scholar 

  4. Raines, E. W. & Ross, R. J. biol. Chem. 257, 5154–5160 (1982).

    CAS  PubMed  Google Scholar 

  5. Pledger, W. J., Stiles, C. D., Antoniades, H. N. & Scher, C. D. Proc. natn. Acad. Sci. U.S.A. 74, 4481–4485 (1977).

    Article  ADS  CAS  Google Scholar 

  6. Stiles, C. D. et al. Proc. natn. Acad. Sci. U.S.A. 76, 1279–1283 (1979).

    Article  ADS  CAS  Google Scholar 

  7. Leof, E. B., Wharton, W., Van Wyk, J. J. & Pledger, W. J. Expl Cell Res. 141, 107–115 (1982).

    Article  CAS  Google Scholar 

  8. Smith, J. C. & Stiles, C. D. Proc. natn. Acad. Sci. U.S.A. 78, 4363–4367 (1981).

    Article  ADS  CAS  Google Scholar 

  9. Cochran, B. H., Reffel, A. C. & Stiles, C. D. Cell 33, 939–947 (1983).

    Article  CAS  PubMed  Google Scholar 

  10. Kelly, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).

    Article  CAS  PubMed  Google Scholar 

  11. Doolittle, R. F. et al. Science 221, 275–277 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Waterfield, M. D. et al. Nature 304, 35–39 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Clarke, M. F. et al. Nature 308, 464–467 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Mellstrom, K. et al. J. Muscle Res. Cell Motility 4, 589–609 (1983).

    Article  Google Scholar 

  15. Bockus, B. J. & Stiles, C. D. Expl Cell Res. 153, 186–197 (1984).

    Article  CAS  Google Scholar 

  16. Shih, C., Pahdy, L. C., Murray, M. & Weinberg, R. A. Nature 290, 261–264 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Krontis, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 78, 1181–1184 (1981).

    Article  ADS  Google Scholar 

  18. Perucho, M. et al. Cell 27, 467–476 (1981).

    Article  CAS  PubMed  Google Scholar 

  19. Berk, A. J. & Sharp, P. A. Cell 12, 721–732 (1977).

    Article  CAS  PubMed  Google Scholar 

  20. Gelmann, E. P., Wong-Staal, F., Kramer, A. R. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 78, 3373–3377 (1981).

    Article  ADS  CAS  Google Scholar 

  21. Southern, P. J. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).

    CAS  Google Scholar 

  22. Battey, J. et al. Cell 34, 779–789 (1983).

    Article  CAS  PubMed  Google Scholar 

  23. Graham, F. L. & Van der Eb, A. J. Virology 52, 456–467 (1973).

    Article  CAS  PubMed  Google Scholar 

  24. Gorman, C. M., Howard, B. H. & Reeves, R. Nucleic Acids Res. 11, 7631–7648 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Sao Paulo, CP 20780, Sao Paulo, Brazil

    H. A. Armelin & M. C. S. Armelin

  2. Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    K. Kelly, T. Stewart & P. Leder

  3. Department of Microbiology and Molecular Genetics, Harvard Medical School and the Dana Farber Cancer Institute, Boston, Massachusetts, 02115, USA

    B. H. Cochran & C. D. Stiles

Authors
  1. H. A. Armelin
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  2. M. C. S. Armelin
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  3. K. Kelly
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  4. T. Stewart
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  5. P. Leder
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  6. B. H. Cochran
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  7. C. D. Stiles
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Armelin, H., Armelin, M., Kelly, K. et al. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature 310, 655–660 (1984). https://doi.org/10.1038/310655a0

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  • DOI: https://doi.org/10.1038/310655a0

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