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Two protein-binding sites in chromatin implicated in the activation of heat-shock genes

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Abstract

The resistance to exonuclease digestion of two regions of chromatin at the 5′ end of heat-shock genes in Drosophila implies they have protein bound to them. The pattern of resistance before and after induction of gene expression suggests that heat-shock genes are activated by the sequential binding of at least two protein factors.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Developmental Biochemistry Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Carl Wu

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Wu, C. Two protein-binding sites in chromatin implicated in the activation of heat-shock genes. Nature 309, 229–234 (1984). https://doi.org/10.1038/309229a0

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  • DOI: https://doi.org/10.1038/309229a0

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