Abstract
In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Valtin, H., Stewart, J. & Sokol, H. W. Handbk Physiol. 7, 131–171 (1974).
Pickering, B. T. & North, W. G. Ann. N. Y. Acad. Sci. 394, 72–81 (1982).
Cheng, S. W. T., North, W. G. & Gellai, M. Ann. N. Y. Acad. 394, 437–480 (1982).
Brownstein, J. M., Russell, J. T. & Gainer, H. Science 207, 373–378 (1980).
Gainer, H. Prog. Brain Res. 60, 205–215 (1982).
Land, H., Schütz, G., Schmale, H. & Richter, D. Nature 295, 299–303 (1982).
Schmale, H., Heinsohn, S. & Richter, D. EMBO J. 2, 763–767 (1983).
Sokol, H. W. & Valtin, H. Ann. N. Y. Acad. Sci. 394, 1–828 (1982).
Valtin, H., North, W. G., LaRochelle, F. T., Sokol, H. W. & Morris, J. Proc. 7th int. Congr. Nephrol., Basel, 313–320 (Karger, Basel, 1978).
Land, H. et al. Nature 302, 342–344 (1983).
Ivell, R. & Richter, D. Proc. natn. Acad. Sci U.S.A. (in the press).
Valtin, H. & Schroeder, H. A. Am. J. Physiol. 206, 425–430 (1964).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Wallace, R. B. et al. Nucleic Acids Res. 6, 3543–3557 (1979).
Breslow, E. A. Rev. Biochem. 48, 251–274 (1979).
Lu, C.-L., Cantin, M., Seidah, N. G. & Chrétien, M. J. Histochem. Cytochem. 30, 999–1003 (1982).
Martin, R. & Voigt, K. H. Nature 289, 502–504 (1981).
Russell, J. T., Brownstein, M. J. & Gainer, H. Endocrinology 107, 1880–1981 (1980).
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294–5299 (1979).
Blin, N. & Stafford, D. W. Nucleic Acids Res. 3, 2303–2308 (1976).
Murray, N. E., Brammar, W. J. & Murray, K. Molec. gen. Genet. 150, 53–61 (1977).
Breathnach, R. & Chambon, P. A. Rev. Biochem. 50, 349–383 (1981).
Gal, A., Nahon, J.-L. & Sala-Trepat, J. M. Analyt. Biochem. 132, 190–194 (1983).
Kidd, V. J., Wallace, R. B., Itakura, K. & Woo, S.L.C. Nature 304, 230–234 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schmale, H., Richter, D. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Nature 308, 705–709 (1984). https://doi.org/10.1038/308705a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/308705a0
- Springer Nature Limited
This article is cited by
-
Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
Journal of Biomedical Science (2020)
-
Viral rescue of magnocellular vasopressin cells in adolescent Brattleboro rats ameliorates diabetes insipidus, but not the hypoaroused phenotype
Scientific Reports (2019)
-
Regression of Walker 256 Carcinosarcoma in Vasopressin-Deficient Brattleboro Rats Is Accompanied by a Changed Laminin Pattern
Biochemical Genetics (2015)
-
Vasopressin signaling at brain level controls stress hormone release: the vasopressin-deficient Brattleboro rat as a model
Amino Acids (2015)
-
Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus
Cell Death & Disease (2014)