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Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei

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Abstract

A computer-based system for recording and analysing light microscope images, combined with classical cytogenetic analysis, has revealed the spatial organization of the giant chromosomes of Drosophila salivary gland cells. Each polytene chromosome arm folds up in a characteristic way, contacts the nuclear surface at specific sites and is topologically isolated from all other arms.

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Author notes

  1. Harald Saumweber

    Present address: Abteilung für Physikalische Biologie, Max-Planck-Institut für Virusforschung, D-7400, Tübingen, 1, FRG

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, 94143, USA

    David Mathog, Mark Hochstrasser, Yosef Gruenbaum, Harald Saumweber & John Sedat

Authors
  1. David Mathog
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  2. Mark Hochstrasser
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  3. Yosef Gruenbaum
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  4. Harald Saumweber
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  5. John Sedat
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Mathog, D., Hochstrasser, M., Gruenbaum, Y. et al. Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei. Nature 308, 414–421 (1984). https://doi.org/10.1038/308414a0

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  • DOI: https://doi.org/10.1038/308414a0

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