Abstract
The cloned cDNAs encoding the four subunits of the Torpedo californica acetylcholine receptor, each carried by a simian virus 40 vector, direct the synthesis of the functional receptor in a combined expression system consisting of COS monkey cells and Xenopus oocytes. Our results suggest that all four subunits are required to elicit a normal nicotinic response to acetylcholine, whereas only the α-subunit is indispensable for α-bungarotoxin binding activity.
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Mishina, M., Kurosaki, T., Tobimatsu, T. et al. Expression of functional acetylcholine receptor from cloned cDNAs. Nature 307, 604–608 (1984). https://doi.org/10.1038/307604a0
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DOI: https://doi.org/10.1038/307604a0
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