Skip to main content
SpringerLink
Log in

A putative second cell-derived oncogene of the avian leukaemia retrovirus E26

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

The acute avian leukaemia retroviruses AMV and E26 both induce myeloblastosis in vivo and transform myeloblasts in vitro1–5. Both viruses contain the oncogene v-myb first described for AMV6,7. Unlike AMV, E26 has the additional capacity to induce erythroblastosis in vivo and to transform erythroblasts4,5. Previous analyses indicated that the genome of E26 also contained nucleotide sequences distinct from v-myb and unrelated to viral replicative genes6,8,9. Using a molecularly cloned E26 provirus, we have now identified a novel nucleotide sequence designated v-ets (for E-twenty-six specific)10 of ∼1.5 kilobase pairs (kbp) located next to v-myb. v-ets possesses all the structural characteristics of a putative new oncogene: it has a conserved cellular counterpart c-ets which is transcribed in some normal chicken cells as a major 7.5-kb polyadenylated RNA. Although our results now await elucidation of their biological significance, we propose that v-ets could be a new oncogene accounting for the additional transforming properties of E26, or potentiating the transforming properties of the v-myb oncogene.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Graf, T. & Stehelin, D. Biochim. biophys. Acta 651, 245–271 (1982).

    CAS  PubMed  Google Scholar 

  2. Beard, J. W. Adv. Cancer Res. 7, 1–127 (1963).

    Article  CAS  PubMed  Google Scholar 

  3. Ivanov, X., Mladenov, Z., Nedyalkov, S. & Todorov, T. G. Bull. Inst. Path. comp. Anim. Domest. 9, 5–36 (1962).

    Google Scholar 

  4. Radke, K., Beug, H., Kornfeld, S. & Graf, T. Cell 31, 643–653 (1982).

    Article  CAS  PubMed  Google Scholar 

  5. Moscovici, M. G. et al. Virology 129, 65–78 (1983).

    Article  CAS  PubMed  Google Scholar 

  6. Roussel, M. et al. Nature 281, 452–455 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Souza, L. M., Strommer, J. N., Hilyard, R. L., Komaromy, M. C. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 77, 5177–5181 (1980).

    Article  ADS  CAS  Google Scholar 

  8. Bister, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 3677–3681 (1982).

    Article  ADS  CAS  Google Scholar 

  9. Stehelin, D. et al. Cold Spring Harb. Symp. quant. Biol. 44, 1215–1223 (1980).

    Article  CAS  PubMed  Google Scholar 

  10. Coffin, J. M. et al. J. Virol. 40, 953–957 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Gonda, T. J. et al. Cell 23, 279–290 (1981).

    Article  CAS  PubMed  Google Scholar 

  12. Saule, S. et al. J. Virol. 42, 71–82 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Delorbe, W. J., Luciw, P. A., Goodman, H. M., Varmus, H. E. & Bishop, J. M. J. Virol. 36, 50–61 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Gonda, T. J. & Bishop, J. M. J. Virol. 46, 212–220 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Leprince, D. et al. EMBOJ J. 2, 1073–1078 (1983).

    Article  CAS  Google Scholar 

  16. Vennstrom, B. & Bishop, J. M. Cell 28, 135–143 (1982).

    Article  CAS  PubMed  Google Scholar 

  17. Sheiness, D., Hughes, S. H., Varmus, H. E., Stubblefield, E. & Bishop, J. M. Virology 105, 415–424 (1980).

    Article  CAS  PubMed  Google Scholar 

  18. Wang, J. Y. J. & Baltimore, D. Molec. cell. Biol. 3, 773–779 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Ellis, R. W. et al. Nature 292, 506–511 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Rushlow, K. E. et al. Science 216, 1421–1423 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Klempnauer, K. H., Gonda, T. J. & Bishop, J. M. Cell 31, 453–463 (1982).

    Article  CAS  PubMed  Google Scholar 

  22. Nazerian, K. & Sharma, J. M. J. natn. Cancer Inst. 54, 277–279 (1979).

    Article  Google Scholar 

  23. Gonda, T. J., Sheiness, D. K. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Beug, H., Hayman, M. J. & Graf, T. EMBO J. 1, 1069–1073 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Boyle, W. J., Lipsick, J. S., Reddy, P. E. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 80, 2834–2838 (1983).

    Article  ADS  CAS  Google Scholar 

  26. Coll, J. et al. EMBO J. 2 (in the press).

  27. Hayman, M. J. et al. Cell 32, 579–588 (1983).

    Article  CAS  PubMed  Google Scholar 

  28. Frykberg, L. et al. Cell 32, 227–238 (1983).

    Article  CAS  PubMed  Google Scholar 

  29. Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–602 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Ruley, H. E. Nature 304, 602–606 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Newbold, R. F. & Overell, R. W. Nature 304, 648–651 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire d'Oncologire Moleculaire, INSERM Unité 186, Institut Pasteur, 15 Rue C. Guerin, Lille Cedex, 59019, France

    D. Leprince, A. Gegonne, J. Coll, C. de Taisne, A. Schneeberger, C. Lagrou & D. Stehelin

Authors
  1. D. Leprince
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Gegonne
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Coll
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. de Taisne
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Schneeberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Lagrou
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D. Stehelin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Leprince, D., Gegonne, A., Coll, J. et al. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature 306, 395–397 (1983). https://doi.org/10.1038/306395a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/306395a0

  • Springer Nature Limited

This article is cited by

Search

Navigation