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A polymorphic DNA marker genetically linked to Huntington's disease

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Abstract

Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.

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Author information

Author notes

  1. Paul C. Watkins

    Present address: Integrated Genetics Inc., 51 New York Avenue, Framingham, Massachusetts, 01701, USA

Authors and Affiliations

  1. Neurology Department and Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA

    James F. Gusella, Mary Anne Anderson, Rudolph E. Tanzi, Paul C. Watkins, Kathleen Ottina & Joseph B. Martin

  2. Hereditary Disease Foundation, 9701 Wilshire Blvd, Beverley Hills, California, 90212, USA

    Nancy S. Wexler & P. Michael Conneally

  3. Department of Medical Genetics, Indiana University Medical Center, Indianapolis, Indiana, 46223, USA

    Margaret R. Wallace

  4. Department of Human Genetics, Roswell Park Memorial Institute, Buffalo, New York, 14263, USA

    Susan L. Naylor & Alan Y. Sakaguchi

  5. Venezuela Collaborative Huntington's Disease Project£,

    Nancy S. Wexler, Anne B. Young, Ira Shoulson & Ernesto Bonilla

Authors
  1. James F. Gusella
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  2. Nancy S. Wexler
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  3. P. Michael Conneally
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  4. Susan L. Naylor
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  5. Mary Anne Anderson
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  6. Rudolph E. Tanzi
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  7. Paul C. Watkins
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  8. Kathleen Ottina
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  9. Margaret R. Wallace
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  10. Alan Y. Sakaguchi
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  11. Anne B. Young
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  12. Ira Shoulson
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  13. Ernesto Bonilla
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  14. Joseph B. Martin
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Gusella, J., Wexler, N., Conneally, P. et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306, 234–238 (1983). https://doi.org/10.1038/306234a0

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  • DOI: https://doi.org/10.1038/306234a0

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