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A cell-surface molecule involved in organ-specific homing of lymphocytes

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Abstract

Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.

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Authors and Affiliations

  1. Laboratory of Experimental Oncology, Department of Pathology, Stanford University School of Medicine, Stanford, California, 94305, USA

    W. Michael Gallatin, Irving L. Weissman & Eugene C. Butcher

Authors
  1. W. Michael Gallatin
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  2. Irving L. Weissman
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  3. Eugene C. Butcher
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Gallatin, W., Weissman, I. & Butcher, E. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304, 30–34 (1983). https://doi.org/10.1038/304030a0

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