Abstract
Cell surface interactions involving carbohydrate may be important in immune recognition. Previous work from this laboratory has demonstrated the presence of ‘lectin-like’ receptors on mouse peritoneal macrophages that bind bacteria by means of their cell wall sugars1–4. Others have shown that Ia molecules can bind antigen at specific sites which may be involved in presenting antigen to the immune system5 and recent work has shown that these molecules can carry carbohydrate determinants6–7. It has also been found that human Ia molecules can bind to carbohydrates8. As cell surface carbohydrate recognition mechanisms have been implicated in other immune interactions9–11 sugar-specific receptors may have a function in self—non-self recognition. We show here that the binding of the bacterium Staphylococcus albus to mouse peritoneal macrophages was inhibited by various conventional and monoclonal antibodies to Ia antigens suggesting that an I-region gene product may be associated with the binding of unopsonized bacteria.
Similar content being viewed by others
References
Ögmundsdottir, H. M. & Weir, D. M. Clin. exp. Immun. 26, 334–339, (1976).
Freimer, N. B. et al. Acta path. microbiol. scand. Sect. B. 86, 53–57 (1978).
Ögmundsdóttir, H. M., Weir, D. M. & Marmion, B. P. Br. J. exp. Path. 59, 1–7 (1978).
Glass, E. J., Stewart, J. & Weir, D. M. Immunology 44, 529–534 (1981).
Clark, R. B., Chiba, J., Zweig, S. E. & Shevach, E. M. Nature 295, 412–414 (1982).
Parish, C. R., Higgins, T. J. & McKenzie, I. F. C. Immunogenetics, 6, 343–354 (1978).
Higgins, T. J., Parish, C. R., Hogarth, P. M., McKenzie, I. F. C. & Hämmerling, G. J. Immunogenetics 11, 467–482 (1980).
Mann, D. L. & Muchmore, A. J. Immun. 124, 2218–2221 (1980).
Amsden, A., Evans, V., Yoshida, T. & Cohen, S. J. Immun. 120, 542–549 (1978).
Fischer, A., Ballet, J. & Criscelli, C. J. clin. Invest. 62, 1005–1013 (1978).
Muchmore, A. & Blaese, R. M. in Proc. Brooke Lodge Symposium 505–517 (Academic, New York, 1979).
Bagg, J., Paxton, I. R. & Weir, D. M. J. clin. Lab. Immun. 6, 165–168 (1981).
Eshdat, Y., Ofek, I., Yahsour Gan, Y., Sharon, N. & Mirelman, D. Biochem. biophys. Res. Commun. 84, 1551–1559 (1978).
Capo, C., Bongrand, P., Benoliel, A. M. & Depieds, R. Immunology 36, 501–608 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stewart, J., Glass, E. & Weir, D. Macrophage binding of Staphylococcus albus is blocked by anti I-region alloantibody. Nature 298, 852–854 (1982). https://doi.org/10.1038/298852a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/298852a0
- Springer Nature Limited
This article is cited by
-
Impairment of monocyte ?lectin-like? receptor activity in Type 1 (insulin-dependent) diabetic patients
Diabetologia (1987)
-
Macrophage signal recognition
Agents and Actions (1984)
-
Modulation of mouse macrophage receptors by various inflammatory agents
Agents and Actions (1984)