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Local cerebral glucose utilization in non-rapid eye movement sleep

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Abstract

Sleep is accompanied by alterations in neurophysiological activity in many discrete regions in the brain1. Such alterations could be expected to be accompanied by corresponding changes in local metabolic rate2. We have now looked for the specific regions involved in sleep, at least in the stages other than rapid eye movement (REM) sleep, by using the [2-14C]deoxyglucose method for measuring local cerebral glucose utilization3 in the rhesus monkey. Contrary to what many have predicted, animals during stages 2–4 of sleep exhibited a non-selective, generalized 30% decrease in cerebral metabolic rate. Of the 75 structures measured, none exhibited a higher rate in non-REM sleep than in wakefulness.

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Authors and Affiliations

  1. Laboratory of Cerebral Metabolism, National Institute of Mental Health, US Public Health Service, Department of Health and Human Services, Bethesda, Maryland, 20205, USA

    C. Kennedy, S. Suda, M. Miyaoka, M. Ito & L. Sokoloff

  2. Biological and Adult Psychiatry Branches, National Institute of Mental Health, US Public Health Service, Department of Health and Human Services, Bethesda, Maryland, 20205, USA

    J. C. Gillin, W. Mendelson & F. I. Storch

  3. Laboratory of Neuropsychology, National Institute of Mental Health, US Public Health Service, Department of Health and Human Services, Bethesda, Maryland, 20205, USA

    R. K. Nakamura & M. Mishkin

  4. Theoretical Statistics and Mathematics Branch, National Institute of Mental Health, US Public Health Service, Department of Health and Human Services, Bethesda, Maryland, 20205, USA

    K. Peetigrew

  5. Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA

    C. Kennedy

Authors
  1. C. Kennedy
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  2. J. C. Gillin
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  3. W. Mendelson
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  4. S. Suda
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  5. M. Miyaoka
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  6. M. Ito
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  7. R. K. Nakamura
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  8. F. I. Storch
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  9. K. Peetigrew
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  10. M. Mishkin
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  11. L. Sokoloff
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Kennedy, C., Gillin, J., Mendelson, W. et al. Local cerebral glucose utilization in non-rapid eye movement sleep. Nature 297, 325–327 (1982). https://doi.org/10.1038/297325a0

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  • DOI: https://doi.org/10.1038/297325a0

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