Abstract
Vitamin A and its derivatives, the retinoids, cause specific alterations in the proximo-distal pattern of regenerating axolotl limbs. In some cases complete limbs grow from carpal level amputations. If retinoids are responsible for changing the positional information of limb cells, these compounds may represent valuable probes for investigating the molecular basis of pattern formation.
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Maden, M. Vitamin A and pattern formation in the regenerating limb. Nature 295, 672–675 (1982). https://doi.org/10.1038/295672a0
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DOI: https://doi.org/10.1038/295672a0
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