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Lack of immune response gene control for induction of epitope-specific suppression by TGAL antigen

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Abstract

Immune response genes in the I region of the mouse major histocompatibility complex (MHC) have been divided operationally according to whether they control responses to antigens which do or do not induce active suppression in non-responder animals (IS and IR genes respectively)1,2. Studies presented here, however, show that the synthetic terpolymer poly-L-(tyrosine, glutamic acid)-poly-DL-alanine-poly-L-lysine (TGAL)3,4, commonly considered the prototype of antigens which do not induce suppression, actually serves as a potent inducer of epitope-specific suppression for antibody responses in non-responder mice.

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Author notes

  1. Takeshi Tokuhisa

    Present address: Laboratories for Immunology, School of Medicine, Chiba University, 1-8-1 Inohana, Chiba, Japan, 280

Authors and Affiliations

  1. Department of Genetics, Stanford University School of Medicine, Stanford, California, 94305, USA

    Leonore A. Herzenberg, Takeshi Tokuhisa, Kyoko Hayakawa & Leonard A. Herzenberg

Authors
  1. Leonore A. Herzenberg
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  2. Takeshi Tokuhisa
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  3. Kyoko Hayakawa
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  4. Leonard A. Herzenberg
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Herzenberg, L., Tokuhisa, T., Hayakawa, K. et al. Lack of immune response gene control for induction of epitope-specific suppression by TGAL antigen. Nature 295, 329–331 (1982). https://doi.org/10.1038/295329a0

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  • DOI: https://doi.org/10.1038/295329a0

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