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Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

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Abstract

Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5′ side (‘upstream’) of c-myc in the same transcriptional orientation; (II) on the 3′ side (‘downstream’) of c-myc in the same orientation; (III) upstream, in the transcriptional orientation opposite to that of c-myc. Thus, activation of adjacent cellular genes by retroviral DNA can involve mechanisms other than provision of a transcriptional promoter.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143, USA

    Gregory S. Payne

  2. Department of Microbiology and Immunology, University of California, San Francisco, California, 94143, USA

    J. Michael Bishop & Harold E. Varmus

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  1. Gregory S. Payne
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  2. J. Michael Bishop
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  3. Harold E. Varmus
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Payne, G., Bishop, J. & Varmus, H. Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature 295, 209–214 (1982). https://doi.org/10.1038/295209a0

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  • DOI: https://doi.org/10.1038/295209a0

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