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Clustered arrangement of immunoglobulin λ constant region genes in man

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Abstract

The immunoglobulin λ light chain locus of man contains six λ-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. The sequences of three of these genes correspond to three known non-allelic λ chain isotypes: Mcg, Ke−Oz− and Ke−Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, λ-like sequences have also been cloned, suggesting that the λ genes form an unexpectedly large family within the human genome.

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Authors and Affiliations

  1. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland, 20205, USA

    Philip A. Hieter, Gregory F. Hollis & Philip Leder

  2. Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Stanley J. Korsmeyer & Thomas A. Waldmann

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  1. Philip A. Hieter
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  2. Gregory F. Hollis
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  3. Stanley J. Korsmeyer
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  4. Thomas A. Waldmann
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  5. Philip Leder
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Hieter, P., Hollis, G., Korsmeyer, S. et al. Clustered arrangement of immunoglobulin λ constant region genes in man. Nature 294, 536–540 (1981). https://doi.org/10.1038/294536a0

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