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Will any dimer do?

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Abstract

New structural information on the interaction of erythropoietin with its receptor suggests that the orientation of receptor dimers is critical to intracellular activation.

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Figure 1: Schematic showing relative orientations of EPO receptor extracellular chains when complexed with EPO1, EMP13, and EMP332.
Figure 2: EPOR complexes capable of signal transduction.

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Acknowledgements

The authors thank R. Stroud for helpful discussions and M. Randal for assistance with graphics.

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Authors and Affiliations

  1. Sunesis Pharmaceuticals, Inc., 3696 Haven Avenue Suite C,, Redwood City, 94063, California, USA

    Marcus D. Ballinger & James A. Wells

Authors
  1. Marcus D. Ballinger
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  2. James A. Wells
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Ballinger, M., Wells, J. Will any dimer do?. Nat Struct Mol Biol 5, 938–940 (1998). https://doi.org/10.1038/2911

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