Abstract
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
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Coleclough, C., Perry, R., Karjalainen, K. et al. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290, 372–378 (1981). https://doi.org/10.1038/290372a0
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DOI: https://doi.org/10.1038/290372a0
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